The root node of piero:substructure_conversion
type: substructure conversion
has child: isomerization-related_FGC
has child: carbon-related_FGC
has child: halogen-related_FGC
has child: hydrogen-related_FGC
has child: metal-related_FGC
has child: nitrogen-related_FGC
has child: oxygen-related_FGC
has child: phosphorus-related_FGC
has child: sulfur-related_FGC
has child: 1._Carbon-related_FunctionalGroupConversion
has child: 2._Hydrogen-related_FunctionalGroupConversion
has child: 3._Isomerization-related_FunctionalGroupConversion
has child: 4._Nitrogen-related_FunctionalGroupConversion
has child: 5._Oxygen-related_FunctionalGroupConversion
has child: 6._Phosphorus-related_FunctionalGroupConversion
has child: 7._Sulfur-related_FunctionalGroupConversion
has child: 8._Halogen-related_FunctionalGroupConversion
has child: 9._Metal-related_FunctionalGroupConversion
has child: C01AA_Aldehyde_to_Secondary_alcohol
has child: C01AB_Ketone_to_Tertiary_alcohol
has child: C01AC_Aldehyde_to_Epoxide
has child: C01AD_Ketone_to_Epoxide
has child: C01AE_Tertiary_alcohol_to_Ketone
has child: C01AF_Aldehyde_to_Cyclic_secondary_alcohol
has child: C01A_Aldol_reaction
has child: C01BA_Ketone_to_Lactone
has child: C01BB_Aldehyde_to_Lactone
has child: C01BC_Tertiary_carbon_to_Alkenyl
has child: C01BD_Tertiary_alcohol_to_Ketone
has child: C01BE_Primary_alcohol_to_Aldehyde
has child: C01BF_Alkenyl_to_Lactone
has child: C01B_Acylation-deacylation
has child: C01CA_Tertiary_alcohol_to_Phenol
has child: C01CB_Tertiary_carbon_to_Aryl
has child: C01CC_Cyclic_amine_to_Aryl
has child: C01CD_Tertiary_alcohol_to_Ketone
has child: C01CE_Secondary_alcohol_to_Aldehyde
has child: C01CF_Amino_acid_to_Oxime
has child: C01CG_Alkyl_carboxylate_to_Alkenyl
has child: C01CH_Hydroxy_carboxylate_to_Ketone
has child: C01C_Carboxylation-decarboxylation
has child: C01DA_Aldehyde_to_Hydroxy_aldehyde
has child: C01D_Formylation-deformylation
has child: C01EA_Methylmutation
has child: C01EB_Aryl_formation
has child: C01EC_Alkenyl_formation
has child: C01ED_Imine_to_N-methyl
has child: C01E_Methylation-demethylation
has child: C01FA_Imine_to_Alkyl_amine
has child: C01FB_Alkenyl_to_Alkyl
has child: C01FD_Alkylation_on_Carbonyl_carbon
has child: C01FE_Epoxidation
has child: C01FF_Cyclopropane_formation
has child: C01FG_Ring_formation_type_1
has child: C01FH_Ring_formation_type_2
has child: C01FI_Ring_formation_type_3
has child: C01FJ_Ring_formation_type_4
has child: C01FK_Ring_formation_type_5
has child: C01FL_Ring_formation_type_6
has child: C01FM_Ring_formation_type_7
has child: C01FN_Ring_formation_type_8
has child: C01FP_Ring_formation_type_9
has child: C01FQ_N-alkylation
has child: C01FS_S-alkylation
has child: C01F_Alkylation-dealkylation
has child: C01GA_Alkenylation_on_Carbonyl_carbon
has child: C01GA_Alkynylation-dealkynylation
has child: C01GA_Cyanation_on_Carbonyl_carbon
has child: C01GB_Cyanation_on_Aryl_carbon
has child: C01GB_Peroxygenation_with_Alkylmutation
has child: C01GC_Transalkylation_on_Cyanide
has child: C01G_Alkenylation-dealkenylation
has child: C01HA_Aryl_ring_addtion_on_Carbonyl_carbon
has child: C01HB_Aryl_ring_addition_on_Double_bond
has child: C01HC_Ring_translocation
has child: C01HD_Ring_coupling_type_1
has child: C01HE_Ring_coupling_type_2
has child: C01H_Arylation-dearylation

1._Carbon-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

2._Hydrogen-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

3._Isomerization-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

4._Nitrogen-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

5._Oxygen-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

6._Phosphorus-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

7._Sulfur-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

8._Halogen-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

9._Metal-related_FunctionalGroupConversion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01AA_Aldehyde_to_Secondary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01AB_Ketone_to_Tertiary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01AC_Aldehyde_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01AD_Ketone_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01AE_Tertiary_alcohol_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01AF_Aldehyde_to_Cyclic_secondary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01A_Aldol_reaction
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01BA_Ketone_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01BB_Aldehyde_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01BC_Tertiary_carbon_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01BD_Tertiary_alcohol_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01BE_Primary_alcohol_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01BF_Alkenyl_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01B_Acylation-deacylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CA_Tertiary_alcohol_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CB_Tertiary_carbon_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CC_Cyclic_amine_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CD_Tertiary_alcohol_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CE_Secondary_alcohol_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CF_Amino_acid_to_Oxime
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CG_Alkyl_carboxylate_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01CH_Hydroxy_carboxylate_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01C_Carboxylation-decarboxylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01DA_Aldehyde_to_Hydroxy_aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01D_Formylation-deformylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01EA_Methylmutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01EB_Aryl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01EC_Alkenyl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01ED_Imine_to_N-methyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01E_Methylation-demethylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FA_Imine_to_Alkyl_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FB_Alkenyl_to_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FD_Alkylation_on_Carbonyl_carbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FE_Epoxidation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FF_Cyclopropane_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FG_Ring_formation_type_1
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FH_Ring_formation_type_2
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FI_Ring_formation_type_3
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FJ_Ring_formation_type_4
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FK_Ring_formation_type_5
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FL_Ring_formation_type_6
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FM_Ring_formation_type_7
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FN_Ring_formation_type_8
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FP_Ring_formation_type_9
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FQ_N-alkylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01FS_S-alkylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01F_Alkylation-dealkylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01GA_Alkenylation_on_Carbonyl_carbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01GA_Alkynylation-dealkynylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01GA_Cyanation_on_Carbonyl_carbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01GB_Cyanation_on_Aryl_carbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01GB_Peroxygenation_with_Alkylmutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01GC_Transalkylation_on_Cyanide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01G_Alkenylation-dealkenylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01HA_Aryl_ring_addtion_on_Carbonyl_carbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01HB_Aryl_ring_addition_on_Double_bond
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01HC_Ring_translocation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01HD_Ring_coupling_type_1
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01HE_Ring_coupling_type_2
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01H_Arylation-dearylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AA_Ketone_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AB_C-acylmutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AC_Ketone_ring_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AD_Amide_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AE_Lactam_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AF_N-oxycarbonyl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AG_Carboxylic_ester_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AH_Lactone_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AI_Lactam_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AJA_Phosphate_to_Acylphosphate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AJ_Aryl_lactone_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AK_Carboxylic_thioester_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AL_Aldehyde_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AM_Methylene_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AN_Methylene_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AO_Phenol_to_Aryl_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02AP_Cyclic_imine_to_Amide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02A_Acylation-deacylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BA_Carboxylation_to_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BB_Carboxylation_on_Alkyl_with_consequences
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BC_Carboxylation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BD_Carboxylation_on_Carbonyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BE_Carboxylation_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BN_N-carboxylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02BO_P-carboxylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02B_Carboxylation-decarboxylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02CA_Formylation_on_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02CB_Formylation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02CC_N-formylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02CD_S-formylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02C_Formylation-deformylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DA_Methylation_on_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DB_Methylation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DC_Methylation_on_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DD_Methylation_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DE_Methylmutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DF_N-methylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DG_Methylation_on_Hydroxy
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DH_Methylation_on_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DI_Methylation_on_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DJ_Methylation_on_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DK_P-methylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DL_S-methylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02DM_Methylation_on_Other_elements
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02D_Methylation-demethylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EA_Alkylation_on_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EB_Alkylation_to_Alkyl_with_consequences
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EC_Alkylation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EDA_Alkylation_on_Cyano
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02ED_Alkylation_on_Carbonyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EE_Alkylation_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EF_Alkylmutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EG_Ring_formation_type_10
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EH_N-alkylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EI_N-alkylation_to_form_Cyclic_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EJ_N-alkylation_to_form_Cyclic_amide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EK_O-alkylation_to_form_Alkyl_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EL_O-alkylation_to_form_Cyclic_alkyl_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EM_O-alkylation_to_form_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EN_O-alkylation_to_form_Cyclic_carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EO_S-alkylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02EP_Alkylation_on_Other_elements
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02E_Alkylation-dealkylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FA_Alkenylation_on_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FA_O-alkenylation_to_form_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FB_Alkenylation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FC_Alkenylation_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FD_N-alkenylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FE_O-alkenylation_to_form_Alkenyl_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FF_O-alkenylation_to_form_Cyclic_alkenyl_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FG_O-alkenylation_to_form_Cyclic_carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FH_S-alkenylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02FI_Alkenylation_on_Other_elements
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02F_Alkenylation-dealkenylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GA_Arylation_on_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GB_Aryl_ring_coupling
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GC_Ring_formation_type_11
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GD_N-arylation_to_form_Secondary_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GE_N-arylation_to_form_Cyclic_secondary_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GF_O-arylation_to_form_Aryl_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02GF_O-arylation_to_form_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02G_Arylation-dearylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02HA_N-arylation_to_form_N-aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02HB_Ring_formation_type_12
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02H_N-aryl_ring_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

C1_residue_epimerization
type: substructure conversion
has parent: R-S_isomerization
has child: tertiary_carbon_carboxylate_epimerization

R-S_isomerization
has child: C1_residue_epimerization
type: substructure conversion
has parent: isomerization-related_FGC
has child: amine_epimerization
has child: amino_acid_and_residue_epimerization
has child: carbohydrate_and_derivative_epimerization
has child: secondary_alcohol_epimerization
has child: hydroxy_acid_epimerization

isomerization-related_FGC
has child: R-S_isomerization
has child: E-Z_isomerization
type: substructure conversion
label: isomerization-related funcional group conversion
has parent: The root node of piero:substructure_conversion
has child: tautomerization

E-Z_isomerization
type: substructure conversion
has parent: isomerization-related_FGC
has child: carbonyl-associated_double_bond_E-Z_isomerization
has child: aryl-associated_double_bond_E-Z_isomerization
has child: conjugated_double_bond_E-Z_isomerization
has child: isolated_double_bond_E-Z_isomerization

H01AA_Primary_alcohol_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AB_Secondary_alcohol_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AC_Cyclic_secondary_alcohol_to_Cyclic_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01ADA_Secondary_alcohol_to_Cyclic_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01ADB_Alkyl_ether_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AD_Cyclic_secondary_alcohol_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AE_Cyclic_hemiacetal_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AFA_Ketone_to_Phenol_with_cyclization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AF_Cyclic_ketone_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AG_Gem-diol_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AH_Alkyl_ether_to_Oxonium
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01AI_Hydroxyamine_to_Nitroso
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01A_Oxygen-related_functional_group_dehydrogenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01BA_Alkyl_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01BBA_Alkyl_to_Aryl_with_cyclization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01BB_Alkyl_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01BD_Cyclic_secondary_alcohol_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01BE_Alkene_to_Alkyne
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01BF_Allene_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01B_Carbon-related_functional_group_dehydrogenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01CA_Amine_to_Imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01CB_Amine_to_Nitrile
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01CC_Cyclic_amine_to_Cyclic_imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01CD_Cyclic_amine_to_Aryl_imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01CE_Aryl_amine_to_Aryl_imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01CE_Cyclic_imine_to_Aryl_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01C_Nitrogen-related_functional_group_dehydrogenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01DA_Hydrogen_sulfide_to_Sulfur
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01D_Sulfur-related_functional_group_dehydrogenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01EA_Transition_metal_Oxidoreduction
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01E_Metal-related_functional_group_oxidoreduction
type: substructure conversion
has parent: The root node of piero:substructure_conversion

H01_Hydrogenation-dehydrogenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01AA_Amino_acid_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01AB_Amino_acid_residue_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01A_Amino_acid_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01BA_Hydroxy_acid_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01B_Hydroxy_acid_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01CA_Carbohydrate_epimerase
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01CB_Carbohydrate_carboxylate_epimerase
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01CC_Carbohydrate_methyl_epimerase
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01C_Carbohydrate_derivative_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01DA_Secondary_alcohol_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01DB_Cyclic_secondary_alcohol_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01D_Secondary_alcohol_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01EA_Amine_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01EB_Cyclic_amine_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01E_Amine_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01FA_C1_residue_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01FB_Carboxylate_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01F_C1_residue_epimerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I01_R-S_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02AA_Aldehyde-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02AB_Ketone-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02AC_Carboxylate-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02A_Carbonyl-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02BA_Aryl-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02B_Aryl-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02CA_Conjugated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02C_Conjugated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02DA_Isolated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02D_Isolated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I02_E-Z_isomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I03AA_Keto-enol_tautomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I03AB_Imine-Enamine_tautomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I03AC_Amide-Iminol_tautomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I03A_Prototropic_tautomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

I03_Tautomerization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N-oxide_formation
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group

oxo_formation_on_nitrogen-related_functional_group
has child: N-oxide_formation
type: substructure conversion
has parent: oxo-formation
has child: nitro_formation
has child: oxidative_deamination
has child: oxo_formation_on_amidine_forming_amide
has child: oxo_formation_on_amino_acid_forming_carbonyl
has child: oxo_formation_on_aryl_amine_ring_open
has child: oxo_formation_on_cyclic_amine_ring_open
has child: oxo_formation_on_enamine_forming_ketone
has child: oxo_formation_on_imine
has child: oxo_formation_on_nitrile_forming_carboxylate

oxo-formation
has child: oxo_formation_on_nitrogen-related_functional_group
has child: oxo_formation_on_sulfur-related_functional_group
type: substructure conversion
has parent: oxygenation-deoxygenation
has child: oxo_formation_on_hydrocarbon
has child: oxo_formation_on_halogen-related_functional_group

N01AA_Deamination_on_Primary_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01AB_Deamination_on_Secondary_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01AC_Deamination_on_Tertiary_ammonium
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01ADA_Hemiaminal_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01AD_Deamination_on_Quartary_ammonium
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01AE_Cyclic_hemiaminal_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01AF_Cyclic_aminal_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01A_Amination-deamination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02AA_Deamination_on_Primary_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02AB_Deamination_on_Secondry_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02AC_Deamination_on_Tertiary_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02AF_Aminomutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02AG_Ring_formation_by_amine_exchange
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02A_Amination-deamination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02BA_Deamination_on_Imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02BB_Deamination_on_Aryl_Imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02BC_Ring_formation_by_amine_exchange
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02B_Imination-deimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

N02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O-alkylation_on_phosphate_ester_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: phospholytic_carbon-oxygen_bond_formation

phospholytic_carbon-oxygen_bond_formation
has child: O-alkylation_on_phosphate_ester_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: phosphorus-related_substitution

phosphorus-related_substitution
has child: phospholytic_carbon-oxygen_bond_formation
has child: phospholytic_carbon-carbon_ring_formation
type: substructure conversion
has parent: phosphorus-related_FGC
has child: phosphomutation
has child: substitutive_phosphorylation-dephosphorylation

O01AA_Primary_alcohol_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AB_Secondary_alcohol_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AC_Cyclic_secondary_alcohol_to_Cyclic_alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AD_Cyclic_secondary_alcohol_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AE_Tertiary_alcohol_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AF_Cyclic_tertiary_alcohol_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AG_Cyclic_tertiary_alcohol_to_Cyclic_alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AH_Cyclic_tertiary_alcohol_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AI_Gem-diol_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AJ_Aldehyde_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AK_Ketone_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AL_Carboxylate_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AM_Hydroxy_amine_to_Imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01AN_Oxime_to_Nitrile
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01A_Hydration
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BA_Carboxylic_ester_addition_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BB_Carboxylic_ester_addition_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BCA_Lactone_formation_by_Carboxylic_ester_addition_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BC_Lactone_formation_by_Carboxylic_ester_addition_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BD_Lactone_formation_by_Carboxylic_ester_addition_on_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BE_Lactone_formation_by_Carboxylic_ester_addition_on_Substituted_alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BF_Lactone_formation_by_Carboxylic_ester_addition_on_Cyclic_alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01BG_Lactone_formation_by_Carboxylic_ester_addition_on_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01B_Carboxylic_ester_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01CA_Alkoxylation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01CB_Alkoxylation_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01CC_Alkoxylation_on_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01CD_Alkoxylation_on_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01CE_Nitrile_to_Oxime
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01C_Alkyl_ether_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DA_Cyclization_on_Hydroxy_and_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DB_Cyclization_on_Hydroxy_and_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DC_Cyclization_on_Carbonyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DD_Oxygenation_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DE_Oxygenation_on_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DF_Aldehyde_addition_on_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01DG_Ring_formation_type_13
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01D_Epoxidation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AA_Lactone_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AB_Carboxylic_ester_exchange
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AC_Carbonyl_exchange
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AD_Aldehyde_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AE_Hydroxy_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AF_Methyl_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AG_Methyl_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AH_Alkyl_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AI_Alkenyl_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AJ_Aldehyde_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AK_Aryl_ether_to_Aryl_lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AL_Halo_alkenyl_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AM_Elimination_of_Carbonyl_to_form_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AO_Alkyl_ether_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02AP_Thioether_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02A_Carboxylate_ester_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BA_Alkyl_to_Alkyl_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BB_Alkyl_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BC_Alkenyl_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BD_Aryl_to_Hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BE_Aryl_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BF_Cyclic_amine_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BG_Cyclic_amine_to_Cyclic_acetal
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BH_Hydroxy_ether_exchange
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BI_Alcohol_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BJ_Alcohol_to_Cyclic_hemiacetal
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BK_Alkenyl_to_Hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BL_Alkenyl_to_Cyclic_acetal
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BM_Aryl_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BN_Carbonyl_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BO_Cyclic_hemiacetal_to_Cyclic_acetal
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02BP_Hydroxy_ketone_to_Hemiacetal
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02B_Ether_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02CA_Alcohol_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02CB_Alkyl_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02CC_Alkenyl_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02CD_Peroxide_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02CE_Thioether_to_Epoxide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02C_Epoxidation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AA_Methyl_to_Primary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AB_Methylene_to_Secondary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03ACA_Methylene_to_Secondary_alcohol_with_cyclization
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AC_Methylene_ring_to_Cyclic_secondary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AD_Tertiary_carbon_to_Tertiary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AE_Tertiary_carbon_ring_to_Cyclic_tertiary_alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AF_Alkenyl_to_Enol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AG_Alkenyl_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AH_Aryl_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AI_Aldehyde_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AJ_Ketone_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AK_Keto_carboxylate_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AM_Substituted_aryl_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03ANA_Alkylcarboxylate_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AN_Aryl_carboxylate_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AO_Substituted_aryl_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AP_Carboxylate_to_Bicarbonate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AQ_Alkyl_C-C_cleavage
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AR_Carboxylate_to_Aryl_carboxylate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AS_Carboxylate_ester_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AT_Substituted_aryl_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AU_Peroxygenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03AV_Hydroxymutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03A_Hydroxylation-dehydroxylation_on_Hydrocarbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BA_Amine_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BB_Amine_to_Enol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BC_Aryl_amine_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BD_Amide_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BE_Lactam_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BF_Aryl_amine_to_Cyclic_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BG_Amine_to_Hydroxy_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BH_Amine_to_Oxime
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BI_Amine_to_Azo
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03BJ_Imine_to_Hydroxy_amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03B_Hydroxylation-dehydroxylation_on_Amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CA_Thiol_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CB_Thioether_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CC_Sulfonium_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CD_Sulfonate_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CE_Sulfonate_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CF_Thioether_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CG_Thiophosphate_to_Phosphate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03CH_Hydroxylation_on_Sulfur
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03C_Hydroxylation-dehydroxylation_on_Sulfurous_compounds
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03DA_Acyl_halide_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03DB_Alkyl_halide_to_Alcohol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03DC_Aryl_halide_to_Phenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03DD_Halophosphate_tp_Phosphate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03D_Hydroxylation-dehydroxylation_on_Halogenous_compounds
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03EA_Hydroxylation-dehydroxylation_on_Other_elements
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03E_Hydroxylation-dehydroxylation_on_Other_elements
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FA_Methyl_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FB_Methyl_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FC_Methylene_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FD_Methylene_ring_open_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FD_Methylene_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FE_Primary_alcohol_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FF_Methylene_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FG_Tertiary_carbon_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FH_Tertiary_carbon_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FJ_Alkenyl_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FK_Alkenyl_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FL_Alkenyl_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FM_Aryl_to_Cyclic_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FN_Aryl_to_Aryl_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FO_Aryl_ring_open_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FP_Aryl_ring_open_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FQ_Aryl_ring_open_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FR_Aryl_ring_open_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03FS_Oxomutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03F_Oxo_formation_on_Carbon
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GA_Nitrile_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GB_Oxidative_deamination_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GC_Imine_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GD_Oxidative_deamination_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GEB_Imine_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GE_Enamine_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GF_Oxidative_deamination_to_Cyclic_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GF_Oxidative_deamination_to_Lactone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GGA_Amidine_to_Amide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GG_Cyclic_enamine_to_Cyclic_ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GH_Aryl_Amidine_to_Aryl_amide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GI_Cyclic_amine_ring_open_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GJ_Cyclic_amine_ring_open_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GK_Aryl_amine_ring_open_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GLA_Aryl_amidine_ring_open_to_Amide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GL_Aryl_amine_ring_open_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GM_Aryl_amine_ring_open_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GO_Amino_acid_to_Carbonyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GP_Cyclic_amine_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GQ_Ring_formation_type_14
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GR_N-oxide_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03GS_Nitro_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03G_Oxo_formation_on_Amine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03HA_S-oxide_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03HB_Thiol_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03HC_Phosphorothioate_to_Phosphate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03H_Oxo_formation_on_Sulforous_compounds
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03IA_Organyl_halide_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03IB_Organyl_halide_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03IC_Oxo_formation_to_halogen_oxoacid
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03I_Oxo_formation_on_Halogenous_compounds
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03JA_Ketone_to_Carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03JB_Cyclic_ketone_to_Cyclic_carboxylic_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03J_Monooxygen_insertion
type: substructure conversion
has parent: The root node of piero:substructure_conversion

O03_Oxygenation-deoxygenation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01AA_Phosphate_ester_to_Aldehyde
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01AB_Phosphate_ester_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01AC_Phosphate_ester_to_Carboxylate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01A_O-P_phosphoaddition-O-phosphoelimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01BA_Phosphate_ester_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01BB_Phosphate_ester_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01B_C-O_phosphoaddition-phosphoelimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01CA_Phosphonate_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01C_C-P_phosphoaddition-phosphoelimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AA_Alcohol_to_Phosphate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AB_Enol_to_Phosphate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AC_Phenol_to_Phosphate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AD_Phosphate_to_Phosphate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AE_Cyclic_phosphate_ester_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AF_Phosphate_to_Phosphoanhydride
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AG_Alkyl_to_Phosphate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AH_Amine_to_Phosphoramide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02AI_Carboxylate_to_Acylphosphate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02A_Phosphorylation-dephosphorylation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02CA_Ring_formation_type_15
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02CB_Ring_formation_type_16
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02CC_Ring_formation_type_17
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02CD_Ring_formation_type_18
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02C_Phospholytic_C-C_ring_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02DA_O-alkylation_on_Phosphate_ester_to_Cyclic_hydroxy_ether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02D_Phospholytic_C-O_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02EA_Phosphomutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02E_Phosphomutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

P02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S-oxide_formation
type: substructure conversion
has parent: oxo_formation_on_sulfur-related_functional_group

oxo_formation_on_sulfur-related_functional_group
has child: S-oxide_formation
type: substructure conversion
has parent: oxo-formation
has child: oxo_formation_on_phosphorothioate_forming_phosphate
has child: oxo_formation_on_thiol_to_aldehyde

S01AA_Alkenyl_to_S-substituted_alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S01AB_Nitrile_to_S-substituted_imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S01A_Thioether_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S01BA_Alkenyl_to_S-substituted_alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S01BB_Nitrile_to_S-substituted_imine
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S01B_Sulfate_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02AA_Alkyl_to_Thiol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02AB_Aryl_to_Aryl_thiol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02AC_Thiol_to_Persulfide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02A_Thiolation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BA_Alkyl_to_Thioether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BB_Alkyl_to_Cyclic_thioether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BC_Alkyl_to_Disulfide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BD_Aryl_to_Aryl_thioether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BE_Thiol_to_Disulfide
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BF_Imine_to_Imine_thioether
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02BG_Thioether_mutation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02B_Thioether_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02CA_Aldehyde_to_Carboxylate_thioester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02CB_Alcohol_to_Carboxylate_thioester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02CC_Epoxide_to_Carboxylate_thioester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02C_Carboxylate_thioester_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DA_Alcohol_to_Sulfate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DB_Ketone_to_Enol_sulfate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DC_Oxime_to_Oxime_sulfate_ester
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DD_Amine_to_Amine_sulfate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DE_Thiol_to_Thiosulfate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DF_Alkyl_to_Sulfonate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DG_Aryl_to_Sulfonate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DH_Ketone_to_Sulfonate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02DI_Phosphate_to_Phosphosulfate
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02D_Sulfate_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02EA_Alkyl_to_Selenol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02E_Selenol_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

S1AC_Transalkylation_on_Thiol
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01AA_Alkyl_halide_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01A_Aryl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01BA_Alkyl_halide_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01B_Alkenyl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01CA_Lactone_halide_to_Ketone
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01C_Acyl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02AA_Aryl_halide_to_Aryl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02A_Aryl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02BA_Alkenyl_halide_to_Alkenyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02B_Alkenyl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02CA_Alkyl_halide_to_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02CB_Alkenyl_halide_to_Alkyl
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02C_Alkyl_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02DA_Halide_to_Elemental_halogen
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02D_Inorganic_halogen_bond_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

X02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

Z01_Addition-elimination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

Z02AA_Alkyl_to_Alkylmetal
type: substructure conversion
has parent: The root node of piero:substructure_conversion

Z02A_C-M_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

Z02BA_Tetrapyrrole_coordination
type: substructure conversion
has parent: The root node of piero:substructure_conversion

Z02B_N-M_formation
type: substructure conversion
has parent: The root node of piero:substructure_conversion

Z02_Substitution
type: substructure conversion
has parent: The root node of piero:substructure_conversion

additive_C-alkylation
type: substructure conversion
has parent: additive_alkylation-dealkylation
has child: additive_alkylation_forming_cyclopropane
has child: additive_alkylation_on_alkenyl_forming_alkyl
has child: additive_alkylation_on_carbonyl_carbon

additive_alkylation-dealkylation
has child: additive_C-alkylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_N-alkylation
has child: additive_O-alkylation
has child: additive_S-alkylation

carbon-related_addition-elimination
has child: additive_alkylation-dealkylation
has child: additive_carboxylation-decarboxylation
has child: additive_methylation-demethylation
has child: additive_acylation-deacylation
type: substructure conversion
label: carbon-related addition-elimination
has parent: carbon-related_FGC
has child: additive_alkenylation-dealkenylation
has child: additive_alkynylation-dealkynylation
has child: additive_arylation-dearylation
has child: additive_formylation-deformylation
has child: aldol_reaction

additive_C-carboxylation_on_aldehyde_forming_alpha-hydroxy_carboxylate
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_carboxylation-decarboxylation
has child: additive_C-carboxylation_on_aldehyde_forming_alpha-hydroxy_carboxylate
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_C-carboxylation_on_alkenyl_forming_alkyl_carboxylate
has child: additive_C-carboxylation_on_aryl_forming_tertiary_carbon_carboxylate
has child: additive_C-carboxylation_on_cyclic_aromatic_amine_forming_cyclic_amine_carboxylate
has child: additive_C-carboxylation_on_ketone_forming_alpha-hydroxy_carboxylate
has child: additive_C-carboxylation_on_oxime_forming_alpha-amino_acid
has child: additive_C-carboxylation_on_phenol_forming_cyclic_alpha-hydroxy_carboxylate

additive_C-carboxylation_on_alkenyl_forming_alkyl_carboxylate
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_C-carboxylation_on_aryl_forming_tertiary_carbon_carboxylate
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_C-carboxylation_on_cyclic_aromatic_amine_forming_cyclic_amine_carboxylate
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_C-carboxylation_on_ketone_forming_alpha-hydroxy_carboxylate
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_C-carboxylation_on_oxime_forming_alpha-amino_acid
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_C-carboxylation_on_phenol_forming_cyclic_alpha-hydroxy_carboxylate
type: substructure conversion
has parent: additive_carboxylation-decarboxylation

additive_C-methylation
type: substructure conversion
has parent: additive_methylation-demethylation
has child: additive_C-methylation_on_aldehyde
has child: additive_C-methylation_on_alkenyl_forming_alkyl-methyl
has child: additive_C-methylation_on_aryl_forming_aryl-methyl
has child: additive_methylmutation

additive_methylation-demethylation
has child: additive_C-methylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_N-methylation_on_Imine_forming_N-methyl

additive_C-methylation_on_aldehyde
type: substructure conversion
has parent: additive_C-methylation

additive_C-methylation_on_alkenyl_forming_alkyl-methyl
type: substructure conversion
has parent: additive_C-methylation

additive_C-methylation_on_aryl_forming_aryl-methyl
type: substructure conversion
has parent: additive_C-methylation

additive_N-alkylation
type: substructure conversion
has parent: additive_alkylation-dealkylation
has child: additive_alkylation_on_imine_forming_alkyl_amine

additive_N-methylation_on_Imine_forming_N-methyl
type: substructure conversion
has parent: additive_methylation-demethylation

additive_O-alkylation
type: substructure conversion
has parent: additive_alkylation-dealkylation
has child: additive_alkylation_forming_epoxide

additive_S-alkylation
type: substructure conversion
has parent: additive_alkylation-dealkylation

additive_acylation-deacylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_acylation_on_aldehyde_forming_lactone
has child: additive_acylation_on_alkenyl_forming_lactone
has child: additive_acylation_on_ketone_forming_lactone
has child: additive_acylation_on_methylene_forming_carboxylic_ester
has child: additive_acylation_on_primary_alcohol_forming_aldehyde
has child: additive_acylation_on_tertiary_alcohol_forming_ketone
has child: additive_acylation_on_tertiary_carbon_forming_alkenyl

carbon-related_FGC
has child: carbon-related_addition-elimination
type: substructure conversion
label: carbon-related functional group conversion
has parent: The root node of piero:substructure_conversion
has child: carbon-related_substitution

additive_acylation_on_aldehyde_forming_lactone
type: substructure conversion
has parent: additive_acylation-deacylation

additive_acylation_on_alkenyl_forming_lactone
type: substructure conversion
has parent: additive_acylation-deacylation

additive_acylation_on_ketone_forming_lactone
type: substructure conversion
has parent: additive_acylation-deacylation

additive_acylation_on_methylene_forming_carboxylic_ester
type: substructure conversion
has parent: additive_acylation-deacylation

additive_acylation_on_primary_alcohol_forming_aldehyde
type: substructure conversion
has parent: additive_acylation-deacylation

additive_acylation_on_tertiary_alcohol_forming_ketone
type: substructure conversion
has parent: additive_acylation-deacylation

additive_acylation_on_tertiary_carbon_forming_alkenyl
type: substructure conversion
has parent: additive_acylation-deacylation

additive_alkenylation-dealkenylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_alkenylation_on_carbonyl_carbon

additive_alkenylation_on_carbonyl_carbon
type: substructure conversion
has parent: additive_alkenylation-dealkenylation

additive_alkoxylation_forming_hydroxyl_ether
type: substructure conversion
has parent: oxygen-related_addition-elimination
has child: additive_alkoxylation_on_aldehyde_forming_hydroxyl_ether
has child: additive_alkoxylation_on_alkenyl_forming_hydroxyl_ether
has child: additive_alkoxylation_on_aryl_forming_hydroxyl_ether
has child: additive_alkoxylation_on_ketone_forming_hydroxyl_ether

oxygen-related_addition-elimination
has child: additive_alkoxylation_forming_hydroxyl_ether
type: substructure conversion
has parent: oxygen-related_FGC
has child: additive_carboxylic_ester_formation
has child: additive_epoxidation
has child: hydration

oxygen-related_FGC
has child: oxygen-related_addition-elimination
has child: oxygenation-deoxygenation
type: substructure conversion
label: oxygen-related functional group conversion
has parent: The root node of piero:substructure_conversion
has child: oxygen-related_substitution

additive_alkoxylation_on_aldehyde_forming_hydroxyl_ether
type: substructure conversion
has parent: additive_alkoxylation_forming_hydroxyl_ether

additive_alkoxylation_on_alkenyl_forming_hydroxyl_ether
type: substructure conversion
has parent: additive_alkoxylation_forming_hydroxyl_ether

additive_alkoxylation_on_aryl_forming_hydroxyl_ether
type: substructure conversion
has parent: additive_alkoxylation_forming_hydroxyl_ether

additive_alkoxylation_on_ketone_forming_hydroxyl_ether
type: substructure conversion
has parent: additive_alkoxylation_forming_hydroxyl_ether

additive_alkylation_forming_cyclopropane
type: substructure conversion
has parent: additive_C-alkylation

additive_alkylation_forming_epoxide
type: substructure conversion
has parent: additive_O-alkylation

additive_alkylation_on_alkenyl_forming_alkyl
type: substructure conversion
has parent: additive_C-alkylation

additive_alkylation_on_carbonyl_carbon
type: substructure conversion
has parent: additive_C-alkylation

additive_alkylation_on_imine_forming_alkyl_amine
type: substructure conversion
has parent: additive_N-alkylation

additive_alkynylation-dealkynylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_cyanation
has child: transalkylation_on_cyanide

additive_amination-deamination
type: substructure conversion
has parent: nitrogen-related_addition-elimination
has child: additive_amination_forming_cyclic_aminal
has child: additive_amination_forming_hemiaminal
has child: additive_amination_forming_quaternary_ammonium
has child: additive_amination_on_alkenyl

nitrogen-related_addition-elimination
has child: additive_amination-deamination
type: substructure conversion
has parent: nitrogen-related_FGC

nitrogen-related_FGC
has child: nitrogen-related_addition-elimination
type: substructure conversion
label: nitrogen-related functional group conversion
has parent: The root node of piero:substructure_conversion
has child: nitrogen-related_substitution

additive_amination_forming_cyclic_aminal
type: substructure conversion
has parent: additive_amination-deamination

additive_amination_forming_cyclic_hemiaminal
type: substructure conversion
has parent: additive_amination_forming_hemiaminal

additive_amination_forming_hemiaminal
has child: additive_amination_forming_cyclic_hemiaminal
type: substructure conversion
has parent: additive_amination-deamination

additive_amination_forming_quaternary_ammonium
type: substructure conversion
has parent: additive_amination-deamination

additive_amination_on_alkenyl
type: substructure conversion
has parent: additive_amination-deamination
has child: additive_amination_on_alkenyl_producing_primary_amine
has child: additive_amination_on_alkenyl_producing_secondary_amine
has child: additive_amination_on_alkenyl_producing_tertiary_ammonium

additive_amination_on_alkenyl_producing_primary_amine
type: substructure conversion
has parent: additive_amination_on_alkenyl

additive_amination_on_alkenyl_producing_secondary_amine
type: substructure conversion
has parent: additive_amination_on_alkenyl

additive_amination_on_alkenyl_producing_tertiary_ammonium
type: substructure conversion
has parent: additive_amination_on_alkenyl

additive_arylation-dearylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_arylation_on_carbonyl_carbon
has child: additive_arylation_on_double_bond
has child: additive_arylation_translocating_ring

additive_arylation_on_carbonyl_carbon
type: substructure conversion
has parent: additive_arylation-dearylation

additive_arylation_on_double_bond
type: substructure conversion
has parent: additive_arylation-dearylation

additive_arylation_translocating_ring
type: substructure conversion
has parent: additive_arylation-dearylation

additive_carboxylic_ester_formation
type: substructure conversion
has parent: oxygen-related_addition-elimination
has child: additive_carboxylic_ester_formation_on_alkenyl
has child: additive_carboxylic_ester_formation_on_aryl
has child: additive_lactone_formation_on_aldehyde
has child: additive_lactone_formation_on_ketone

additive_carboxylic_ester_formation_on_alkenyl
type: substructure conversion
has parent: additive_carboxylic_ester_formation
has child: additive_lactone_formation_on_alkenyl
has child: additive_lactone_formation_on_cyclic_alkenyl
has child: additive_lactone_formation_on_substituted_alkenyl

additive_carboxylic_ester_formation_on_aryl
type: substructure conversion
has parent: additive_carboxylic_ester_formation
has child: additive_lactone_formation_on_aryl

additive_cyanation
type: substructure conversion
has parent: additive_alkynylation-dealkynylation
has child: additive_cyanation_on_aryl_carbon
has child: additive_cyanation_on_carbonyl_carbon

additive_cyanation_on_aryl_carbon
type: substructure conversion
has parent: additive_cyanation

additive_cyanation_on_carbonyl_carbon
type: substructure conversion
has parent: additive_cyanation

additive_epoxidation
type: substructure conversion
has parent: oxygen-related_addition-elimination
has child: additive_epoxide_formation_from_aldehyde_and_alkenyl
has child: additive_epoxide_formation_from_carbonyl
has child: additive_epoxide_formation_from_hydroxy_and_alkenyl
has child: additive_epoxide_formation_from_hydroxy_and_aryl
has child: additive_oxygenation_on_alkenyl_forming_epoxide
has child: additive_oxygenation_on_aryl_forming_epoxide

additive_epoxide_formation_from_aldehyde_and_alkenyl
type: substructure conversion
has parent: additive_epoxidation

additive_epoxide_formation_from_carbonyl
type: substructure conversion
has parent: additive_epoxidation

additive_epoxide_formation_from_hydroxy_and_alkenyl
type: substructure conversion
has parent: additive_epoxidation

additive_epoxide_formation_from_hydroxy_and_aryl
type: substructure conversion
has parent: additive_epoxidation

additive_formylation-deformylation
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: additive_formylation_on_aldehyde_forming_alpha-hydroxy_aldehyde

additive_formylation_on_aldehyde_forming_alpha-hydroxy_aldehyde
type: substructure conversion
has parent: additive_formylation-deformylation

additive_halogenization_on_alkenyl_forming_alkyl_halide
type: substructure conversion
has parent: additive_halogenizing_alkyl_halide_formation

additive_halogenizing_alkyl_halide_formation
has child: additive_halogenization_on_alkenyl_forming_alkyl_halide
type: substructure conversion
has parent: halogen-related_addition-elimination
has child: additive_halogenization_on_aryl_forming_alkyl_halide

halogen-related_addition-elimination
has child: additive_halogenizing_alkyl_halide_formation
has child: additive_halogenizing_lactone_halide_formation
type: substructure conversion
label: halogen-related addition-elimination
has parent: halogen-related_FGC

additive_halogenization_on_aryl_forming_alkyl_halide
type: substructure conversion
has parent: additive_halogenizing_alkyl_halide_formation

additive_halogenization_on_ketone_forming_lactone_halide
type: substructure conversion
has parent: additive_halogenizing_lactone_halide_formation

additive_halogenizing_lactone_halide_formation
has child: additive_halogenization_on_ketone_forming_lactone_halide
type: substructure conversion
has parent: halogen-related_addition-elimination

halogen-related_FGC
has child: halogen-related_addition-elimination
type: substructure conversion
label: halogen-related functional group conversion
has parent: The root node of piero:substructure_conversion
has child: halogen-related_substitution

additive_lactone_formation_on_aldehyde
type: substructure conversion
has parent: additive_carboxylic_ester_formation

additive_lactone_formation_on_alkenyl
type: substructure conversion
has parent: additive_carboxylic_ester_formation_on_alkenyl

additive_lactone_formation_on_aryl
type: substructure conversion
has parent: additive_carboxylic_ester_formation_on_aryl

additive_lactone_formation_on_cyclic_alkenyl
type: substructure conversion
has parent: additive_carboxylic_ester_formation_on_alkenyl

additive_lactone_formation_on_ketone
type: substructure conversion
has parent: additive_carboxylic_ester_formation

additive_lactone_formation_on_substituted_alkenyl
type: substructure conversion
has parent: additive_carboxylic_ester_formation_on_alkenyl

additive_methylmutation
type: substructure conversion
has parent: additive_C-methylation

additive_oxygenation_on_alkenyl_forming_epoxide
type: substructure conversion
has parent: additive_epoxidation

additive_oxygenation_on_aryl_forming_epoxide
type: substructure conversion
has parent: additive_epoxidation

additive_phosphorylation-dephosphorylation
type: substructure conversion
has parent: phosphorus-related_addition-elimination
has child: additive_phosphorylation_on_aldehyde_forming_phosphate_ester
has child: additive_phosphorylation_on_alkenyl_forming_phosphate_ester
has child: additive_phosphorylation_on_alkenyl_forming_phosphonate
has child: additive_phosphorylation_on_aryl_forming_phosphate_ester
has child: additive_phosphorylation_on_carboxylate_forming_phosphate_ester
has child: additive_phosphorylation_on_ketone_forming_phosphate_ester

phosphorus-related_addition-elimination
has child: additive_phosphorylation-dephosphorylation
type: substructure conversion
has parent: phosphorus-related_FGC

phosphorus-related_FGC
has child: phosphorus-related_addition-elimination
has child: phosphorus-related_substitution
type: substructure conversion
label: phosphorus-related functional group conversion
has parent: The root node of piero:substructure_conversion

additive_phosphorylation_on_aldehyde_forming_phosphate_ester
type: substructure conversion
has parent: additive_phosphorylation-dephosphorylation

additive_phosphorylation_on_alkenyl_forming_phosphate_ester
type: substructure conversion
has parent: additive_phosphorylation-dephosphorylation

additive_phosphorylation_on_alkenyl_forming_phosphonate
type: substructure conversion
has parent: additive_phosphorylation-dephosphorylation

additive_phosphorylation_on_aryl_forming_phosphate_ester
type: substructure conversion
has parent: additive_phosphorylation-dephosphorylation

additive_phosphorylation_on_carboxylate_forming_phosphate_ester
type: substructure conversion
has parent: additive_phosphorylation-dephosphorylation

additive_phosphorylation_on_ketone_forming_phosphate_ester
type: substructure conversion
has parent: additive_phosphorylation-dephosphorylation

additive_sulfate_formation
type: substructure conversion
has parent: sulfur-related_addition-elimination
has child: additive_sulfate_formation_on_alkenyl_forming_S-substituted_alkyl
has child: additive_sulfate_formation_on_nitrile_forming_S-substituted_imine

sulfur-related_addition-elimination
has child: additive_sulfate_formation
type: substructure conversion
has parent: sulfur-related_FGC
has child: additive_sulfide_formation

sulfur-related_FGC
has child: sulfur-related_addition-elimination
has child: sulfur-related_substitution
type: substructure conversion
label: sulfur-related functional group conversion
has parent: The root node of piero:substructure_conversion

additive_sulfate_formation_on_alkenyl_forming_S-substituted_alkyl
type: substructure conversion
has parent: additive_sulfate_formation

additive_sulfate_formation_on_nitrile_forming_S-substituted_imine
type: substructure conversion
has parent: additive_sulfate_formation

additive_sulfide_formation
type: substructure conversion
has parent: sulfur-related_addition-elimination
has child: additive_sulfide_formation_on_alkenyl_forming_S-substituted_alkyl
has child: additive_sulfide_formation_on_nitrile_forming_S-substituted_imine
has child: additive_transalkylation_on_thiol

additive_sulfide_formation_on_alkenyl_forming_S-substituted_alkyl
type: substructure conversion
has parent: additive_sulfide_formation

additive_sulfide_formation_on_nitrile_forming_S-substituted_imine
type: substructure conversion
has parent: additive_sulfide_formation

additive_transalkylation_on_thiol
type: substructure conversion
has parent: additive_sulfide_formation

aldehyde-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: carbonyl-associated_double_bond_E-Z_isomerization

carbonyl-associated_double_bond_E-Z_isomerization
has child: aldehyde-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: E-Z_isomerization
has child: carboxylate-associated_double_bond_E-Z_isomerization
has child: ketone-associated_double_bond_E-Z_isomerization

aldol_reaction
type: substructure conversion
has parent: carbon-related_addition-elimination
has child: aldol_reaction_on_aldehyde_forming_secondary_alcohol
has child: aldol_reaction_on_aldehyde_forming_epoxide
has child: aldol_reaction_on_ketone_forming_epoxide
has child: aldol_reaction_on_ketone_forming_tertiary_alcohol

aldol_reaction_on_aldehyde_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: aldol_reaction_on_aldehyde_forming_secondary_alcohol

aldol_reaction_on_aldehyde_forming_secondary_alcohol
has child: aldol_reaction_on_aldehyde_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: aldol_reaction

aldol_reaction_on_aldehyde_forming_epoxide
type: substructure conversion
has parent: aldol_reaction

aldol_reaction_on_ketone_forming_epoxide
type: substructure conversion
has parent: aldol_reaction

aldol_reaction_on_ketone_forming_tertiary_alcohol
type: substructure conversion
has parent: aldol_reaction

amide-iminol_tautomerization
type: substructure conversion
has parent: prototropic_tautomerization

prototropic_tautomerization
has child: amide-iminol_tautomerization
type: substructure conversion
has parent: tautomerization
has child: imine-enamine_tautomerization
has child: keto-enol_tautomerization

tautomerization
has child: prototropic_tautomerization
type: substructure conversion
has parent: isomerization-related_FGC

amine_epimerization
type: substructure conversion
has parent: R-S_isomerization
has child: cyclic_amine_epimerization

amino_acid_and_residue_epimerization
type: substructure conversion
has parent: R-S_isomerization
has child: amino_acid_epimerization
has child: amino_acid_residue_epimerization

amino_acid_epimerization
type: substructure conversion
has parent: amino_acid_and_residue_epimerization

amino_acid_residue_epimerization
type: substructure conversion
has parent: amino_acid_and_residue_epimerization

aryl-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: E-Z_isomerization

aryl_ring_coupling
type: substructure conversion
has parent: substitutive_C-arylation

substitutive_C-arylation
has child: aryl_ring_coupling
type: substructure conversion
has parent: substitutive_arylation-dearylation
has child: substitutive_C-arylation_on_alkyl

substitutive_arylation-dearylation
has child: substitutive_C-arylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-arylation_forming_secondary_amine
has child: substitutive_O-arylation

carbohydrate_and_derivative_epimerization
type: substructure conversion
has parent: R-S_isomerization
has child: carbohydrate_carboxylate_epimerase
has child: carbohydrate_epimerase
has child: carbohydrate_methyl_epimerase

carbohydrate_carboxylate_epimerase
type: substructure conversion
has parent: carbohydrate_and_derivative_epimerization

carbohydrate_epimerase
type: substructure conversion
has parent: carbohydrate_and_derivative_epimerization

carbohydrate_methyl_epimerase
type: substructure conversion
has parent: carbohydrate_and_derivative_epimerization

carbon-related_functional_group_dehydrogenation
type: substructure conversion
has parent: hydrogenation-dehydrogenation
has child: dehydrogenization_on_alkenyl_forming_alkynyl
has child: dehydrogenization_on_alkyl_forming_alkenyl
has child: dehydrogenization_on_alkyl_forming_aryl
has child: dehydrogenization_on_allene_forming_alkenyl
has child: dehydrogenization_on_cyclic_secondary_alcohol_forming_phenol

hydrogenation-dehydrogenation
has child: carbon-related_functional_group_dehydrogenation
type: substructure conversion
has parent: hydrogen-related_FGC
has child: nitrogen-related_functional_group_dehydrogenation
has child: oxygen-related_functional_group_dehydrogenation
has child: sulfur-related_functional_group_dehydrogenation
has child: metal-related_functional_group_oxidoreduction

hydrogen-related_FGC
has child: hydrogenation-dehydrogenation
type: substructure conversion
label: hydrogen-related functional group conversion
has parent: The root node of piero:substructure_conversion

carbon-related_substitution
type: substructure conversion
label: carbon-related substitution
has parent: carbon-related_FGC
has child: substitutive_acylation-deacylation
has child: substitutive_alkenylation-dealkenylation
has child: substitutive_alkylation-dealkylation
has child: substitutive_arylation-dearylation
has child: substitutive_carboxylation-decarboxylation
has child: substitutive_formylation-deformylation
has child: substitutive_methylation-demethylation
has child: substitutive_N-aryl_ring_formation

carboxylate-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: carbonyl-associated_double_bond_E-Z_isomerization

conjugated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: E-Z_isomerization

cyclic_amine_epimerization
type: substructure conversion
has parent: amine_epimerization

cyclic_secondary_alcohol_epimerization
type: substructure conversion
has parent: secondary_alcohol_epimerization

secondary_alcohol_epimerization
has child: cyclic_secondary_alcohol_epimerization
type: substructure conversion
has parent: R-S_isomerization

dehydrogenization_on_alkenyl_forming_alkynyl
type: substructure conversion
has parent: carbon-related_functional_group_dehydrogenation

dehydrogenization_on_alkyl_forming_alkenyl
type: substructure conversion
has parent: carbon-related_functional_group_dehydrogenation

dehydrogenization_on_alkyl_forming_aryl
type: substructure conversion
has parent: carbon-related_functional_group_dehydrogenation

dehydrogenization_on_allene_forming_alkenyl
type: substructure conversion
has parent: carbon-related_functional_group_dehydrogenation

dehydrogenization_on_amine_forming_imine
type: substructure conversion
has parent: nitrogen-related_functional_group_dehydrogenation
has child: dehydrogenization_on_cyclic_amine_forming_cyclic_imine

nitrogen-related_functional_group_dehydrogenation
has child: dehydrogenization_on_amine_forming_imine
type: substructure conversion
has parent: hydrogenation-dehydrogenation
has child: dehydrogenization_on_amine_forming_nitrile
has child: dehydrogenization_on_aryl_aromatic_amine_forming_aryl_aromatic_imine
has child: dehydrogenization_on_cyclic_amine_forming_aryl_aromatic_imine
has child: dehydrogenization_on_cyclic_imine_forming_aryl_aromatic_amine

dehydrogenization_on_amine_forming_nitrile
type: substructure conversion
has parent: nitrogen-related_functional_group_dehydrogenation

dehydrogenization_on_aryl_aromatic_amine_forming_aryl_aromatic_imine
type: substructure conversion
has parent: nitrogen-related_functional_group_dehydrogenation

dehydrogenization_on_cyclic_amine_forming_aryl_aromatic_imine
type: substructure conversion
has parent: nitrogen-related_functional_group_dehydrogenation

dehydrogenization_on_cyclic_amine_forming_cyclic_imine
type: substructure conversion
has parent: dehydrogenization_on_amine_forming_imine

dehydrogenization_on_cyclic_hemiacetal_forming_lactone
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

oxygen-related_functional_group_dehydrogenation
has child: dehydrogenization_on_cyclic_hemiacetal_forming_lactone
type: substructure conversion
has parent: hydrogenation-dehydrogenation
has child: dehydrogenization_on_cyclic_ketone_forming_phenol
has child: dehydrogenization_on_secondary_alcohol_forming_ketone
has child: dehydrogenization_on_gem-diol_forming_carboxylate
has child: dehydrogenization_on_hydroxyamine_forming_nitroso
has child: dehydrogenization_on_hydroxyl_ether_forming_ketone
has child: dehydrogenization_on_hydroxyl_ether_forming_oxonium
has child: dehydrogenization_on_ketone_forming_phenol
has child: dehydrogenization_on_primary_alcohol_forming_aldehyde

dehydrogenization_on_cyclic_imine_forming_aryl_aromatic_amine
type: substructure conversion
has parent: nitrogen-related_functional_group_dehydrogenation

dehydrogenization_on_cyclic_ketone_forming_phenol
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_cyclic_secondary_alcohol_forming_cyclic_ketone
type: substructure conversion
has parent: dehydrogenization_on_secondary_alcohol_forming_ketone

dehydrogenization_on_secondary_alcohol_forming_ketone
has child: dehydrogenization_on_cyclic_secondary_alcohol_forming_cyclic_ketone
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation
has child: dehydrogenization_on_cyclic_secondary_alcohol_forming_ketone
has child: dehydrogenization_on_secondary_alcohol_forming_cyclic_ketone

dehydrogenization_on_cyclic_secondary_alcohol_forming_ketone
type: substructure conversion
has parent: dehydrogenization_on_secondary_alcohol_forming_ketone

dehydrogenization_on_cyclic_secondary_alcohol_forming_phenol
type: substructure conversion
has parent: carbon-related_functional_group_dehydrogenation

dehydrogenization_on_gem-diol_forming_carboxylate
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_hydrogen_sulfide_forming_sulfur
type: substructure conversion
has parent: sulfur-related_functional_group_dehydrogenation

sulfur-related_functional_group_dehydrogenation
has child: dehydrogenization_on_hydrogen_sulfide_forming_sulfur
type: substructure conversion
has parent: hydrogenation-dehydrogenation

dehydrogenization_on_hydroxyamine_forming_nitroso
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_hydroxyl_ether_forming_ketone
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_hydroxyl_ether_forming_oxonium
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_ketone_forming_phenol
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_primary_alcohol_forming_aldehyde
type: substructure conversion
has parent: oxygen-related_functional_group_dehydrogenation

dehydrogenization_on_secondary_alcohol_forming_cyclic_ketone
type: substructure conversion
has parent: dehydrogenization_on_secondary_alcohol_forming_ketone

halogen-related_substitution
type: substructure conversion
has parent: halogen-related_FGC
has child: inorganic_halogen_bond_formation
has child: substitutive_halogenization_on_alkenyl
has child: substitutive_halogenization_on_aryl

hydration
type: substructure conversion
has parent: oxygen-related_addition-elimination
has child: hydration_on_aldehyde_forming_gem-diol
has child: hydration_on_alkenyl_forming_aldehyde
has child: hydration_on_alkenyl_forming_carboxylate
has child: hydration_on_alkenyl_forming_tertiary_alcohol
has child: hydration_on_alkenyl_forming_ketone
has child: hydration_on_alkenyl_forming_primary_alcohol
has child: hydration_on_alkenyl_forming_secondary_alcohol
has child: hydration_on_aryl_forming_cyclic_secondary_alcohol
has child: hydration_on_aryl_forming_cyclic_tertiary_alcohol
has child: hydration_on_imine_forming_hydroxy_amine
has child: hydration_on_nitrile_forming_oxime

hydration_on_aldehyde_forming_gem-diol
type: substructure conversion
has parent: hydration

hydration_on_alkenyl_forming_aldehyde
type: substructure conversion
has parent: hydration

hydration_on_alkenyl_forming_carboxylate
type: substructure conversion
has parent: hydration

hydration_on_alkenyl_forming_cyclic_tertiary_alcohol
type: substructure conversion
has parent: hydration_on_alkenyl_forming_tertiary_alcohol

hydration_on_alkenyl_forming_tertiary_alcohol
has child: hydration_on_alkenyl_forming_cyclic_tertiary_alcohol
type: substructure conversion
has parent: hydration
has child: hydration_on_cyclic_alkenyl_forming_cyclic_tertiary_alcohol

hydration_on_alkenyl_forming_ketone
type: substructure conversion
has parent: hydration

hydration_on_alkenyl_forming_primary_alcohol
type: substructure conversion
has parent: hydration

hydration_on_alkenyl_forming_secondary_alcohol
type: substructure conversion
has parent: hydration
has child: hydration_on_cyclic_alkenyl_forming_cyclic_secondary_alcohol

hydration_on_aryl_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: hydration

hydration_on_aryl_forming_cyclic_tertiary_alcohol
type: substructure conversion
has parent: hydration

hydration_on_cyclic_alkenyl_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: hydration_on_alkenyl_forming_secondary_alcohol

hydration_on_cyclic_alkenyl_forming_cyclic_tertiary_alcohol
type: substructure conversion
has parent: hydration_on_alkenyl_forming_tertiary_alcohol

hydration_on_imine_forming_hydroxy_amine
type: substructure conversion
has parent: hydration

hydration_on_nitrile_forming_oxime
type: substructure conversion
has parent: hydration

hydroxy_acid_epimerization
type: substructure conversion
has parent: R-S_isomerization

hydroxylation-dehydroxylation
type: substructure conversion
has parent: oxygenation-deoxygenation
has child: hydroxylation_on_hydrocarbon
has child: hydroxylation_on_halogen-related_functional_group
has child: hydroxylation_on_nitrogen-related_functional_group
has child: hydroxylation_on_other_elements-related_functional_group
has child: hydroxylation_on_sulfur-related_functional_group

oxygenation-deoxygenation
has child: hydroxylation-dehydroxylation
type: substructure conversion
has parent: oxygen-related_FGC
has child: monooxygen_insertion
has child: oxo-formation

hydroxylation_ketone_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxylation_on_hydrocarbon
has child: hydroxylation_ketone_forming_carboxylate
type: substructure conversion
has parent: hydroxylation-dehydroxylation
has child: hydroxylation_on_alcohol_forming_alkyl_carboxylate
has child: hydroxylation_on_aldehyde_forming_carboxylate
has child: hydroxylation_on_alkenyl
has child: hydroxylation_on_alkyl
has child: hydroxylation_on_aryl
has child: hydroxylation_on_aryl_carboxylate_forming_phenol
has child: hydroxylation_on_aryl_carboxylic_ester_forming_carboxylate
has child: hydroxylation_on_carboxylate_forming_bicarbonate
has child: hydroxylative_decarboxylation_on_keto_carboxylate_forming_carboxylate
has child: hydroxymutation
has child: peroxygenation

hydroxylation_on_acyl_halide_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_halogen-related_functional_group

hydroxylation_on_halogen-related_functional_group
has child: hydroxylation_on_acyl_halide_forming_carboxylate
type: substructure conversion
has parent: hydroxylation-dehydroxylation
has child: hydroxylation_on_alkyl_halide_forming_alcohol
has child: hydroxylation_on_aryl_halide_forming_phenol
has child: hydroxylation_on_halophosphate_forming_phosphate

hydroxylation_on_alcohol_forming_alkyl_carboxylate
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxylation_on_aldehyde_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxylation_on_alkenyl
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon
has child: hydroxylation_on_alkenyl_forming_enol
has child: hydroxylation_on_alkenyl_forming_phenol

hydroxylation_on_alkenyl_forming_enol
type: substructure conversion
has parent: hydroxylation_on_alkenyl

hydroxylation_on_alkenyl_forming_phenol
type: substructure conversion
has parent: hydroxylation_on_alkenyl

hydroxylation_on_alkyl
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon
has child: hydroxylation_on_alkyl_cleaving_C-C_bond
has child: hydroxylation_on_methyl_forming_primary_alcohol
has child: hydroxylation_on_methylene_forming_secondary_alcohol
has child: hydroxylation_on_tertiary_carbon_forming_tertiary_alcohol

hydroxylation_on_alkyl_cleaving_C-C_bond
type: substructure conversion
has parent: hydroxylation_on_alkyl

hydroxylation_on_alkyl_halide_forming_alcohol
type: substructure conversion
has parent: hydroxylation_on_halogen-related_functional_group

hydroxylation_on_amide_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_nitrogen-related_functional_group
has child: hydroxylation_on_lactam_forming_carboxylate

hydroxylation_on_nitrogen-related_functional_group
has child: hydroxylation_on_amide_forming_carboxylate
type: substructure conversion
has parent: hydroxylation-dehydroxylation
has child: hydroxylation_on_amine
has child: hydroxylation_on_imine_producing_hydroxy_amine

hydroxylation_on_amine
type: substructure conversion
has parent: hydroxylation_on_nitrogen-related_functional_group
has child: hydroxylation_on_amine_forming_azo
has child: hydroxylation_on_amine_producing_alcohol
has child: hydroxylation_on_amine_producing_enol
has child: hydroxylation_on_amine_producing_hydroxy_amine
has child: hydroxylation_on_amine_producing_oxime
has child: hydroxylation_on_aryl_amine_producing_phenol
has child: hydroxylation_on_aryl_aromatic_amine_forming_cyclic_ketone

hydroxylation_on_amine_forming_azo
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_amine_producing_alcohol
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_amine_producing_enol
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_amine_producing_hydroxy_amine
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_amine_producing_oxime
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_aryl
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon
has child: hydroxylation_on_aryl_forming_carboxylic_ester
has child: hydroxylation_on_aryl_forming_phenol
has child: hydroxylation_on_substituted_aryl_forming_alcohol

hydroxylation_on_aryl_amine_producing_phenol
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_aryl_aromatic_amine_forming_cyclic_ketone
type: substructure conversion
has parent: hydroxylation_on_amine

hydroxylation_on_aryl_carboxylate_forming_phenol
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxylation_on_aryl_carboxylic_ester_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxylation_on_aryl_forming_carboxylic_ester
type: substructure conversion
has parent: hydroxylation_on_aryl

hydroxylation_on_aryl_forming_phenol
type: substructure conversion
has parent: hydroxylation_on_aryl
has child: hydroxylation_on_substituted_aryl_forming_phenol

hydroxylation_on_aryl_halide_forming_phenol
type: substructure conversion
has parent: hydroxylation_on_halogen-related_functional_group

hydroxylation_on_carboxylate_forming_bicarbonate
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxylation_on_halophosphate_forming_phosphate
type: substructure conversion
has parent: hydroxylation_on_halogen-related_functional_group

hydroxylation_on_imine_producing_hydroxy_amine
type: substructure conversion
has parent: hydroxylation_on_nitrogen-related_functional_group

hydroxylation_on_lactam_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_amide_forming_carboxylate

hydroxylation_on_methyl_forming_primary_alcohol
type: substructure conversion
has parent: hydroxylation_on_alkyl

hydroxylation_on_methylene_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: hydroxylation_on_methylene_forming_secondary_alcohol

hydroxylation_on_methylene_forming_secondary_alcohol
has child: hydroxylation_on_methylene_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: hydroxylation_on_alkyl
has child: hydroxylation_on_methylene_ring_forming_cyclic_secondary_alcohol

hydroxylation_on_methylene_ring_forming_cyclic_secondary_alcohol
type: substructure conversion
has parent: hydroxylation_on_methylene_forming_secondary_alcohol

hydroxylation_on_other_elements-related_functional_group
type: substructure conversion
has parent: hydroxylation-dehydroxylation

hydroxylation_on_substituted_aryl_forming_alcohol
type: substructure conversion
has parent: hydroxylation_on_aryl

hydroxylation_on_substituted_aryl_forming_phenol
type: substructure conversion
has parent: hydroxylation_on_aryl_forming_phenol

hydroxylation_on_sulfonate_forming_alcohol
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_sulfur-related_functional_group
has child: hydroxylation_on_sulfonate_forming_alcohol
type: substructure conversion
has parent: hydroxylation-dehydroxylation
has child: hydroxylation_on_sulfonate_forming_phenol
has child: hydroxylation_on_sulfonium_forming_alcohol
has child: hydroxylation_on_sulfur
has child: hydroxylation_on_thioether_forming_alcohol
has child: hydroxylation_on_thioether_forming_carboxylate
has child: hydroxylation_on_thiol_forming_alcohol
has child: hydroxylation_on_thiophosphate_forming_phosphate

hydroxylation_on_sulfonate_forming_phenol
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_sulfonium_forming_alcohol
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_sulfur
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_tertiary_carbon_forming_tertiary_alcohol
type: substructure conversion
has parent: hydroxylation_on_alkyl
has child: hydroxylation_on_tertiary_carbon_ring_forming_cyclic_tertiary_alcohol

hydroxylation_on_tertiary_carbon_ring_forming_cyclic_tertiary_alcohol
type: substructure conversion
has parent: hydroxylation_on_tertiary_carbon_forming_tertiary_alcohol

hydroxylation_on_thioether_forming_alcohol
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_thioether_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_thiol_forming_alcohol
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylation_on_thiophosphate_forming_phosphate
type: substructure conversion
has parent: hydroxylation_on_sulfur-related_functional_group

hydroxylative_decarboxylation_on_keto_carboxylate_forming_carboxylate
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

hydroxymutation
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

imine-enamine_tautomerization
type: substructure conversion
has parent: prototropic_tautomerization

inorganic_halogen_bond_formation
type: substructure conversion
has parent: halogen-related_substitution

isolated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: E-Z_isomerization

keto-enol_tautomerization
type: substructure conversion
has parent: prototropic_tautomerization

ketone-associated_double_bond_E-Z_isomerization
type: substructure conversion
has parent: carbonyl-associated_double_bond_E-Z_isomerization

metal-related_FGC
type: substructure conversion
label: metal-related functional group conversion
has parent: The root node of piero:substructure_conversion
has child: metal-related_addition-elimination
has child: metal-related_substitution

metal-related_addition-elimination
type: substructure conversion
has parent: metal-related_FGC

metal-related_functional_group_oxidoreduction
type: substructure conversion
has parent: hydrogenation-dehydrogenation
has child: oxidoreduction_on_transition_metal

metal-related_substitution
type: substructure conversion
has parent: metal-related_FGC
has child: substitutive_carbon-metal_bond_formation
has child: substitutive_nitrogen-metal_bond_formation

monooxygen_insertion
type: substructure conversion
has parent: oxygenation-deoxygenation
has child: monooxygen_insertion_on_ketone_forming_carboxylic_ester

monooxygen_insertion_on_cyclic_ketone_forming_cyclic_carboxylic_ester
type: substructure conversion
has parent: monooxygen_insertion_on_ketone_forming_carboxylic_ester

monooxygen_insertion_on_ketone_forming_carboxylic_ester
has child: monooxygen_insertion_on_cyclic_ketone_forming_cyclic_carboxylic_ester
type: substructure conversion
has parent: monooxygen_insertion

nitro_formation
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group

nitrogen-related_substitution
type: substructure conversion
has parent: nitrogen-related_FGC
has child: substitutive_amination-deamination
has child: substitutive_imination-deimination

oxidative_deamination
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group
has child: oxidative_deamination_on_amine_forming_aldehyde
has child: oxidative_deamination_on_amine_forming_ketone
has child: oxidative_deamination_on_amine_forming_lactone

oxidative_deamination_on_amine_forming_aldehyde
type: substructure conversion
has parent: oxidative_deamination

oxidative_deamination_on_amine_forming_cyclic_ketone
type: substructure conversion
has parent: oxidative_deamination_on_amine_forming_ketone

oxidative_deamination_on_amine_forming_ketone
has child: oxidative_deamination_on_amine_forming_cyclic_ketone
type: substructure conversion
has parent: oxidative_deamination

oxidative_deamination_on_amine_forming_lactone
type: substructure conversion
has parent: oxidative_deamination

oxidoreduction_on_transition_metal
type: substructure conversion
has parent: metal-related_functional_group_oxidoreduction

oxo_formation_on_alkenyl
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon
has child: oxo_formation_on_alkenyl_forming_aldehyde
has child: oxo_formation_on_alkenyl_forming_carboxylate
has child: oxo_formation_on_alkenyl_forming_ketone

oxo_formation_on_hydrocarbon
has child: oxo_formation_on_alkenyl
type: substructure conversion
has parent: oxo-formation
has child: oxo_formation_on_aryl
has child: oxo_formation_on_methyl
has child: oxo_formation_on_methylene
has child: oxo_formation_on_primary_alcohol_forming_carboxylate
has child: oxo_formation_on_tertiary_carbon
has child: oxomutation

oxo_formation_on_alkenyl_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_alkenyl

oxo_formation_on_alkenyl_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_alkenyl

oxo_formation_on_alkenyl_forming_ketone
type: substructure conversion
has parent: oxo_formation_on_alkenyl

oxo_formation_on_amidine_forming_amide
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group
has child: oxo_formation_on_aryl_amidine_forming_aryl_amide

oxo_formation_on_amino_acid_forming_carbonyl
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group

oxo_formation_on_aryl
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon
has child: oxo_formation_on_aryl_forming_aldehyde
has child: oxo_formation_on_aryl_forming_aryl_ketone
has child: oxo_formation_on_aryl_forming_carboxylate
has child: oxo_formation_on_aryl_forming_carboxylic_ester
has child: oxo_formation_on_aryl_forming_cyclic_ketone
has child: oxo_formation_on_aryl_forming_linear_ketone

oxo_formation_on_aryl_amidine_forming_aryl_amide
type: substructure conversion
has parent: oxo_formation_on_amidine_forming_amide

oxo_formation_on_aryl_amidine_ring_open_to_amide
type: substructure conversion
has parent: oxo_formation_on_aryl_amine_ring_open

oxo_formation_on_aryl_amine_ring_open
has child: oxo_formation_on_aryl_amidine_ring_open_to_amide
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group
has child: oxo_formation_on_aryl_amine_ring_open_to_aldehyde
has child: oxo_formation_on_aryl_amine_ring_open_to_carboxylate
has child: oxo_formation_on_aryl_amine_ring_open_to_ketone

oxo_formation_on_aryl_amine_ring_open_to_aldehyde
type: substructure conversion
has parent: oxo_formation_on_aryl_amine_ring_open

oxo_formation_on_aryl_amine_ring_open_to_carboxylate
type: substructure conversion
has parent: oxo_formation_on_aryl_amine_ring_open

oxo_formation_on_aryl_amine_ring_open_to_ketone
type: substructure conversion
has parent: oxo_formation_on_aryl_amine_ring_open

oxo_formation_on_aryl_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_aryl

oxo_formation_on_aryl_forming_aryl_ketone
type: substructure conversion
has parent: oxo_formation_on_aryl

oxo_formation_on_aryl_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_aryl

oxo_formation_on_aryl_forming_carboxylic_ester
type: substructure conversion
has parent: oxo_formation_on_aryl

oxo_formation_on_aryl_forming_cyclic_ketone
type: substructure conversion
has parent: oxo_formation_on_aryl

oxo_formation_on_aryl_forming_linear_ketone
type: substructure conversion
has parent: oxo_formation_on_aryl

oxo_formation_on_cyclic_amine_ring_open
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group
has child: oxo_formation_on_cyclic_amine_ring_open_to_aldehyde
has child: oxo_formation_on_cyclic_amine_ring_open_to_carboxylate
has child: oxo_formation_on_cyclic_amine_ring_open_to_ketone

oxo_formation_on_cyclic_amine_ring_open_to_aldehyde
type: substructure conversion
has parent: oxo_formation_on_cyclic_amine_ring_open

oxo_formation_on_cyclic_amine_ring_open_to_carboxylate
type: substructure conversion
has parent: oxo_formation_on_cyclic_amine_ring_open

oxo_formation_on_cyclic_amine_ring_open_to_ketone
type: substructure conversion
has parent: oxo_formation_on_cyclic_amine_ring_open

oxo_formation_on_cyclic_enamine_forming_cyclic_ketone
type: substructure conversion
has parent: oxo_formation_on_enamine_forming_ketone

oxo_formation_on_enamine_forming_ketone
has child: oxo_formation_on_cyclic_enamine_forming_cyclic_ketone
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group

oxo_formation_on_halogen-related_functional_group
type: substructure conversion
has parent: oxo-formation
has child: oxo_formation_on_organyl_halide_forming_aldehyde
has child: oxo_formation_on_organyl_halide_forming_carboxylate
has child: oxo_formation_to_halogen_oxoacid

oxo_formation_on_imine
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group
has child: oxo_formation_on_imine_forming_aldehyde
has child: oxo_formation_on_imine_forming_ketone

oxo_formation_on_imine_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_imine

oxo_formation_on_imine_forming_ketone
type: substructure conversion
has parent: oxo_formation_on_imine

oxo_formation_on_methyl
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon
has child: oxo_formation_on_methyl_forming_aldehyde
has child: oxo_formation_on_methyl_forming_carboxylate

oxo_formation_on_methyl_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_methyl

oxo_formation_on_methyl_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_methyl

oxo_formation_on_methylene
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon
has child: oxo_formation_on_methylene_forming_aldehyde
has child: oxo_formation_on_methylene_forming_carboxylate
has child: oxo_formation_on_methylene_forming_ketone

oxo_formation_on_methylene_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_methylene
has child: oxo_formation_on_methylene_ring_forming_aldehyde

oxo_formation_on_methylene_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_methylene

oxo_formation_on_methylene_forming_ketone
type: substructure conversion
has parent: oxo_formation_on_methylene

oxo_formation_on_methylene_ring_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_methylene_forming_aldehyde

oxo_formation_on_nitrile_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_nitrogen-related_functional_group

oxo_formation_on_organyl_halide_forming_aldehyde
type: substructure conversion
has parent: oxo_formation_on_halogen-related_functional_group

oxo_formation_on_organyl_halide_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_halogen-related_functional_group

oxo_formation_on_phosphorothioate_forming_phosphate
type: substructure conversion
has parent: oxo_formation_on_sulfur-related_functional_group

oxo_formation_on_primary_alcohol_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon

oxo_formation_on_tertiary_carbon
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon
has child: oxo_formation_on_tertiary_carbon_forming_carboxylate
has child: oxo_formation_on_tertiary_carbon_forming_ketone

oxo_formation_on_tertiary_carbon_forming_carboxylate
type: substructure conversion
has parent: oxo_formation_on_tertiary_carbon

oxo_formation_on_tertiary_carbon_forming_ketone
type: substructure conversion
has parent: oxo_formation_on_tertiary_carbon

oxo_formation_on_thiol_to_aldehyde
type: substructure conversion
has parent: oxo_formation_on_sulfur-related_functional_group

oxo_formation_to_halogen_oxoacid
type: substructure conversion
has parent: oxo_formation_on_halogen-related_functional_group

oxomutation
type: substructure conversion
has parent: oxo_formation_on_hydrocarbon

oxygen-related_substitution
type: substructure conversion
has parent: oxygen-related_FGC
has child: substitutive_carboxylic_ester_formation
has child: substitutive_hydroxy_ether_formation

peroxygenation
type: substructure conversion
has parent: hydroxylation_on_hydrocarbon

phospholytic_carbon-carbon_ring_formation
type: substructure conversion
has parent: phosphorus-related_substitution

phosphomutation
type: substructure conversion
has parent: phosphorus-related_substitution

substitutive_C-acylation
type: substructure conversion
has parent: substitutive_acylation-deacylation
has child: substitutive_C-acylation_forming_ketone
has child: substitutive_C-acylation_on_methylene_forming_ketone
has child: substitutive_C-acylation_on_phenol_forming_aryl_aromatic_ketone
has child: substitutive_C-acylmutation

substitutive_acylation-deacylation
has child: substitutive_C-acylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-acylation
has child: substitutive_O-acylation
has child: substitutive_S-acylation

substitutive_C-acylation_forming_ketone
type: substructure conversion
has parent: substitutive_C-acylation
has child: substitutive_acylation_forming_cyclic_ketone

substitutive_C-acylation_on_methylene_forming_ketone
type: substructure conversion
has parent: substitutive_C-acylation

substitutive_C-acylation_on_phenol_forming_aryl_aromatic_ketone
type: substructure conversion
has parent: substitutive_C-acylation

substitutive_C-acylmutation
type: substructure conversion
has parent: substitutive_C-acylation

substitutive_C-alkenylation
type: substructure conversion
has parent: substitutive_alkenylation-dealkenylation
has child: substitutive_alkenylation_on_alkenyl
has child: substitutive_alkenylation_on_alkyl
has child: substitutive_alkenylation_on_aryl

substitutive_alkenylation-dealkenylation
has child: substitutive_C-alkenylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-alkenylation
has child: substitutive_O-alkenylation
has child: substitutive_S-alkenylation
has child: substitutive_alkenylation_on_other_elements

substitutive_C-alkoxylation_on_aldehyde_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_carboxylic_ester_formation
has child: substitutive_C-alkoxylation_on_carbonyl_forming_lactone
has child: substitutive_alkoxylation_on_aldehyde_forming_lactone

substitutive_carboxylic_ester_formation
has child: substitutive_C-alkoxylation_on_aldehyde_forming_carboxylic_ester
type: substructure conversion
has parent: oxygen-related_substitution
has child: substitutive_C-carboxylation_forming_carboxylic_ester
has child: substitutive_O-acylation_forming_carboxylic_ester
has child: substitutive_carbonyl_exchange
has child: substitutive_carboxylic_ester_exchange
has child: substitutive_lactone_formation

substitutive_C-alkoxylation_on_carbonyl_forming_lactone
type: substructure conversion
has parent: substitutive_C-alkoxylation_on_aldehyde_forming_carboxylic_ester

substitutive_C-alkylation
type: substructure conversion
has parent: substitutive_alkylation-dealkylation
has child: substitutive_C-alkylation_on_alkenyl
has child: substitutive_C-alkylation_on_alkyl
has child: substitutive_C-alkylation_on_aryl
has child: substitutive_C-alkylation_on_carbonyl
has child: substitutive_C-alkylation_on_nitrile
has child: substitutive_C-alkylmutation

substitutive_alkylation-dealkylation
has child: substitutive_C-alkylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-alkylation
has child: substitutive_O-alkylation
has child: substitutive_S-alkylation
has child: substitutive_alkylation_on_other_elements

substitutive_C-alkylation_on_alkenyl
type: substructure conversion
has parent: substitutive_C-alkylation

substitutive_C-alkylation_on_alkyl
type: substructure conversion
has parent: substitutive_C-alkylation

substitutive_C-alkylation_on_aryl
type: substructure conversion
has parent: substitutive_C-alkylation

substitutive_C-alkylation_on_carbonyl
type: substructure conversion
has parent: substitutive_C-alkylation

substitutive_C-alkylation_on_nitrile
type: substructure conversion
has parent: substitutive_C-alkylation

substitutive_C-alkylmutation
type: substructure conversion
has parent: substitutive_C-alkylation

substitutive_C-arylation_on_alkyl
type: substructure conversion
has parent: substitutive_C-arylation

substitutive_C-carboxylation
type: substructure conversion
has parent: substitutive_carboxylation-decarboxylation
has child: substitutive_C-carboxylation_on_alkenyl
has child: substitutive_C-carboxylation_on_alkyl
has child: substitutive_C-carboxylation_on_aryl
has child: substitutive_C-carboxylation_on_carbonyl

substitutive_carboxylation-decarboxylation
has child: substitutive_C-carboxylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-carboxylation
has child: substitutive_P-carboxylation

substitutive_C-carboxylation_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_carboxylic_ester_formation
has child: substitutive_C-carboxylation_on_alkenyl_forming_lactone
has child: substitutive_C-carboxylation_on_alkyl_forming_lactone
has child: substitutive_C-carboxylation_on_halo_alkenyl_forming_lactone
has child: substitutive_C-carboxylation_on_methyl_forming_carboxylic_ester
has child: substitutive_C-carboxylation_on_thioether_forming_lactone

substitutive_C-carboxylation_on_alkenyl
type: substructure conversion
has parent: substitutive_C-carboxylation

substitutive_C-carboxylation_on_alkenyl_forming_lactone
type: substructure conversion
has parent: substitutive_C-carboxylation_forming_carboxylic_ester

substitutive_C-carboxylation_on_alkyl
type: substructure conversion
has parent: substitutive_C-carboxylation

substitutive_C-carboxylation_on_alkyl_forming_lactone
type: substructure conversion
has parent: substitutive_C-carboxylation_forming_carboxylic_ester

substitutive_C-carboxylation_on_aryl
type: substructure conversion
has parent: substitutive_C-carboxylation

substitutive_C-carboxylation_on_carbonyl
type: substructure conversion
has parent: substitutive_C-carboxylation

substitutive_C-carboxylation_on_halo_alkenyl_forming_lactone
type: substructure conversion
has parent: substitutive_C-carboxylation_forming_carboxylic_ester

substitutive_C-carboxylation_on_methyl_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_C-carboxylation_forming_carboxylic_ester

substitutive_C-carboxylation_on_thioether_forming_lactone
type: substructure conversion
has parent: substitutive_C-carboxylation_forming_carboxylic_ester

substitutive_C-etherification
type: substructure conversion
has parent: substitutive_hydroxy_ether_formation
has child: substitutive_C-etherification_on_alkyl_forming_alkyl_ether
has child: substitutive_C-etherification_on_alkenyl_forming_hydroxy_ether
has child: substitutive_C-etherification_on_aryl_forming_hydroxy_ether
has child: substitutive_C-etherification_on_cyclic_amine

substitutive_hydroxy_ether_formation
has child: substitutive_C-etherification
type: substructure conversion
has parent: oxygen-related_substitution
has child: substitutive_O-etherification
has child: substitutive_epoxidation
has child: substitutive_hydroxy_ether_exchange

substitutive_C-etherification_on_alkenyl_forming_cyclic_acetal
type: substructure conversion
has parent: substitutive_C-etherification_on_alkyl_forming_alkyl_ether

substitutive_C-etherification_on_alkyl_forming_alkyl_ether
has child: substitutive_C-etherification_on_alkenyl_forming_cyclic_acetal
type: substructure conversion
has parent: substitutive_C-etherification
has child: substitutive_etherification_on_alkyl_forming_cyclic_hydroxy_ether

substitutive_C-etherification_on_alkenyl_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_C-etherification_on_alkenyl_forming_hydroxy_ether

substitutive_C-etherification_on_alkenyl_forming_hydroxy_ether
has child: substitutive_C-etherification_on_alkenyl_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_C-etherification

substitutive_C-etherification_on_aryl_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_C-etherification_on_aryl_forming_hydroxy_ether

substitutive_C-etherification_on_aryl_forming_hydroxy_ether
has child: substitutive_C-etherification_on_aryl_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_C-etherification

substitutive_C-etherification_on_cyclic_amine
type: substructure conversion
has parent: substitutive_C-etherification
has child: substitutive_C-etherification_on_cyclic_amine_forming_cyclic_acetal
has child: substitutive_C-etherification_on_cyclic_amine_forming_cyclic_hydroxy_ether

substitutive_C-etherification_on_cyclic_amine_forming_cyclic_acetal
type: substructure conversion
has parent: substitutive_C-etherification_on_cyclic_amine

substitutive_C-etherification_on_cyclic_amine_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_C-etherification_on_cyclic_amine

substitutive_C-formylation
type: substructure conversion
has parent: substitutive_formylation-deformylation
has child: substitutive_C-formylation_on_alkenyl
has child: substitutive_C-formylation_on_alkyl

substitutive_formylation-deformylation
has child: substitutive_C-formylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-formylation
has child: substitutive_S-formylation

substitutive_C-formylation_on_alkenyl
type: substructure conversion
has parent: substitutive_C-formylation

substitutive_C-formylation_on_alkyl
type: substructure conversion
has parent: substitutive_C-formylation

substitutive_C-methylation
type: substructure conversion
has parent: substitutive_methylation-demethylation
has child: substitutive_C-methylation_on_alkenyl
has child: substitutive_C-methylation_on_alkyl
has child: substitutive_C-methylation_on_aryl
has child: substitutive_methylmutation

substitutive_methylation-demethylation
has child: substitutive_C-methylation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-methylation
has child: substitutive_O-methylation
has child: substitutive_P-methylation
has child: substitutive_S-methylation
has child: substitutive_methylation_on_other_elements

substitutive_C-methylation_on_alkenyl
type: substructure conversion
has parent: substitutive_C-methylation

substitutive_C-methylation_on_alkyl
type: substructure conversion
has parent: substitutive_C-methylation

substitutive_C-methylation_on_aryl
type: substructure conversion
has parent: substitutive_C-methylation

substitutive_C-sulfidation_on_alcohol_forming_carboxylic_thioester
type: substructure conversion
has parent: substitutive_carboxylic_thioester_formation

substitutive_carboxylic_thioester_formation
has child: substitutive_C-sulfidation_on_alcohol_forming_carboxylic_thioester
type: substructure conversion
has parent: sulfur-related_substitution
has child: substitutive_C-sulfidation_on_aldehyde_forming_carboxylic_thioester
has child: substitutive_C-sulfidation_on_epoxide_forming_carboxylic_thioester

sulfur-related_substitution
has child: substitutive_carboxylic_thioester_formation
type: substructure conversion
has parent: sulfur-related_FGC
has child: substitutive_selenol_formation
has child: substitutive_sulfate_formation
has child: substitutive_sulfide_formation
has child: substitutive_thiolation

substitutive_C-sulfidation_on_aldehyde_forming_carboxylic_thioester
type: substructure conversion
has parent: substitutive_carboxylic_thioester_formation

substitutive_C-sulfidation_on_epoxide_forming_carboxylic_thioester
type: substructure conversion
has parent: substitutive_carboxylic_thioester_formation

substitutive_N-acylation
type: substructure conversion
has parent: substitutive_acylation-deacylation
has child: substitutive_N-acylation_forming_N-oxycarbonyl
has child: substitutive_N-acylation_forming_amide
has child: substitutive_N-acylation_forming_lactam

substitutive_N-acylation_forming_N-oxycarbonyl
type: substructure conversion
has parent: substitutive_N-acylation

substitutive_N-acylation_forming_amide
type: substructure conversion
has parent: substitutive_N-acylation
has child: substitutive_N-acylation_forming_lactam
has child: substitutive_N-acylation_on_cyclic_imine_forming_amide

substitutive_N-acylation_forming_lactam
type: substructure conversion
has parent: substitutive_N-acylation
has parent: substitutive_N-acylation_forming_amide

substitutive_N-acylation_on_cyclic_imine_forming_amide
type: substructure conversion
has parent: substitutive_N-acylation_forming_amide

substitutive_N-alkenylation
type: substructure conversion
has parent: substitutive_alkenylation-dealkenylation

substitutive_N-alkylation
type: substructure conversion
has parent: substitutive_alkylation-dealkylation
has child: substitutive_N-alkylation_forming_cyclic_amide
has child: substitutive_N-alkylation_to_form_cyclic_amine

substitutive_N-alkylation_forming_cyclic_amide
type: substructure conversion
has parent: substitutive_N-alkylation

substitutive_N-alkylation_to_form_cyclic_amine
type: substructure conversion
has parent: substitutive_N-alkylation

substitutive_N-aryl_ring_formation
type: substructure conversion
has parent: carbon-related_substitution
has child: substitutive_N-arylation_forming_N-aryl

substitutive_N-arylation_forming_N-aryl
type: substructure conversion
has parent: substitutive_N-aryl_ring_formation

substitutive_N-arylation_forming_cyclic_secondary_amine
type: substructure conversion
has parent: substitutive_N-arylation_forming_secondary_amine

substitutive_N-arylation_forming_secondary_amine
has child: substitutive_N-arylation_forming_cyclic_secondary_amine
type: substructure conversion
has parent: substitutive_arylation-dearylation

substitutive_N-carboxylation
type: substructure conversion
has parent: substitutive_carboxylation-decarboxylation

substitutive_N-formylation
type: substructure conversion
has parent: substitutive_formylation-deformylation

substitutive_N-methylation
type: substructure conversion
has parent: substitutive_methylation-demethylation

substitutive_O-acylation
type: substructure conversion
has parent: substitutive_acylation-deacylation
has child: substitutive_O-acylation_forming_acyl_phosphate
has child: substitutive_O-acylation_forming_carboxylic_ester
has child: substitutive_O-acylation_forming_lactone

substitutive_O-acylation_forming_acyl_phosphate
type: substructure conversion
has parent: substitutive_O-acylation

substitutive_O-acylation_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_carboxylic_ester_formation
has parent: substitutive_O-acylation
has child: substitutive_O-acylation_on_alkyl_ether_forming_lactone
has child: substitutive_O-acylation_on_aryl_ether_forming_aryl_lactone
has child: substitutive_O-acylation_on_hydroxy_forming_carboxylic_ester

substitutive_O-acylation_forming_lactone
type: substructure conversion
has parent: substitutive_O-acylation
has child: substitutive_acylation_forming_aryl_aromatic_lactone

substitutive_O-acylation_on_alkyl_ether_forming_lactone
type: substructure conversion
has parent: substitutive_O-acylation_forming_carboxylic_ester

substitutive_O-acylation_on_aryl_ether_forming_aryl_lactone
type: substructure conversion
has parent: substitutive_O-acylation_forming_carboxylic_ester

substitutive_O-acylation_on_hydroxy_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_O-acylation_forming_carboxylic_ester

substitutive_O-alkenylation
type: substructure conversion
has parent: substitutive_alkenylation-dealkenylation
has child: substitutive_O-alkenylation_forming_alkenyl_ether
has child: substitutive_O-alkenylation_forming_carboxylic_ester

substitutive_O-alkenylation_forming_alkenyl_ether
type: substructure conversion
has parent: substitutive_O-alkenylation
has child: substitutive_O-alkenylation_forming_cyclic_alkenyl_ether

substitutive_O-alkenylation_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_O-alkenylation
has child: substitutive_O-alkenylation_forming_cyclic_carboxylic_ester

substitutive_O-alkenylation_forming_cyclic_alkenyl_ether
type: substructure conversion
has parent: substitutive_O-alkenylation_forming_alkenyl_ether

substitutive_O-alkenylation_forming_cyclic_carboxylic_ester
type: substructure conversion
has parent: substitutive_O-alkenylation_forming_carboxylic_ester

substitutive_O-alkylation
type: substructure conversion
has parent: substitutive_alkylation-dealkylation
has child: substitutive_O-alkylation_forming_alkyl_ether
has child: substitutive_O-alkylation_forming_carboxylic_ester
has child: substitutive_O-alkylation_forming_cyclic_alkyl_ether
has child: substitutive_O-alkylation_forming_cyclic_carboxylic_ester

substitutive_O-alkylation_forming_alkyl_ether
type: substructure conversion
has parent: substitutive_O-alkylation

substitutive_O-alkylation_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_O-alkylation

substitutive_O-alkylation_forming_cyclic_alkyl_ether
type: substructure conversion
has parent: substitutive_O-alkylation

substitutive_O-alkylation_forming_cyclic_carboxylic_ester
type: substructure conversion
has parent: substitutive_O-alkylation

substitutive_O-arylation
type: substructure conversion
has parent: substitutive_arylation-dearylation
has child: substitutive_O-arylation_forming_aryl_ether
has child: substitutive_O-arylation_forming_carboxylic_ester

substitutive_O-arylation_forming_aryl_ether
type: substructure conversion
has parent: substitutive_O-arylation

substitutive_O-arylation_forming_carboxylic_ester
type: substructure conversion
has parent: substitutive_O-arylation

substitutive_O-etherification
type: substructure conversion
has parent: substitutive_hydroxy_ether_formation
has child: substitutive_O-etherification_on_alcohol_forming_cyclic_hydroxy_ether
has child: substitutive_O-etherification_on_carbonyl_forming_cyclic_hydroxy_ether
has child: substitutive_O-etherification_on_cyclic_hemiacetal_forming_cyclic_acetal

substitutive_O-etherification_on_alcohol_forming_cyclic_hemiacetal
type: substructure conversion
has parent: substitutive_O-etherification_on_alcohol_forming_cyclic_hydroxy_ether
has child: substitutive_O-etherification_on_hydroxy_ketone_forming_hemiacetal

substitutive_O-etherification_on_alcohol_forming_cyclic_hydroxy_ether
has child: substitutive_O-etherification_on_alcohol_forming_cyclic_hemiacetal
type: substructure conversion
has parent: substitutive_O-etherification

substitutive_O-etherification_on_carbonyl_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_O-etherification

substitutive_O-etherification_on_cyclic_hemiacetal_forming_cyclic_acetal
type: substructure conversion
has parent: substitutive_O-etherification

substitutive_O-etherification_on_hydroxy_ketone_forming_hemiacetal
type: substructure conversion
has parent: substitutive_O-etherification_on_alcohol_forming_cyclic_hemiacetal

substitutive_O-methylation
type: substructure conversion
has parent: substitutive_methylation-demethylation
has child: substitutive_O-methylation_on_carboxylate
has child: substitutive_O-methylation_on_hydroxy
has child: substitutive_O-methylation_on_ketone

substitutive_O-methylation_on_carboxylate
type: substructure conversion
has parent: substitutive_O-methylation

substitutive_O-methylation_on_hydroxy
type: substructure conversion
has parent: substitutive_O-methylation

substitutive_O-methylation_on_ketone
type: substructure conversion
has parent: substitutive_O-methylation

substitutive_P-carboxylation
type: substructure conversion
has parent: substitutive_carboxylation-decarboxylation

substitutive_P-methylation
type: substructure conversion
has parent: substitutive_methylation-demethylation

substitutive_S-acylation
type: substructure conversion
has parent: substitutive_acylation-deacylation
has child: substitutive_S-acylation_forming_carboxylic_thioester

substitutive_S-acylation_forming_carboxylic_thioester
type: substructure conversion
has parent: substitutive_S-acylation

substitutive_S-alkenylation
type: substructure conversion
has parent: substitutive_alkenylation-dealkenylation

substitutive_S-alkylation
type: substructure conversion
has parent: substitutive_alkylation-dealkylation

substitutive_S-formylation
type: substructure conversion
has parent: substitutive_formylation-deformylation

substitutive_S-methylation
type: substructure conversion
has parent: substitutive_methylation-demethylation

substitutive_acylation_forming_aryl_aromatic_lactone
type: substructure conversion
has parent: substitutive_O-acylation_forming_lactone

substitutive_acylation_forming_cyclic_ketone
type: substructure conversion
has parent: substitutive_C-acylation_forming_ketone

substitutive_alkenylation_on_alkenyl
type: substructure conversion
has parent: substitutive_C-alkenylation

substitutive_alkenylation_on_alkyl
type: substructure conversion
has parent: substitutive_C-alkenylation

substitutive_alkenylation_on_aryl
type: substructure conversion
has parent: substitutive_C-alkenylation

substitutive_alkenylation_on_other_elements
type: substructure conversion
has parent: substitutive_alkenylation-dealkenylation

substitutive_alkoxylation_on_aldehyde_forming_lactone
type: substructure conversion
has parent: substitutive_C-alkoxylation_on_aldehyde_forming_carboxylic_ester

substitutive_alkylation_on_other_elements
type: substructure conversion
has parent: substitutive_alkylation-dealkylation

substitutive_amination-deamination
type: substructure conversion
has parent: nitrogen-related_substitution
has child: substitutive_amination_forming_primary_amine
has child: substitutive_amination_forming_secondry_amine
has child: substitutive_amination_forming_tertiary_amine
has child: substitutive_amine_exchange_forming_ring
has child: substitutive_aminomutation

substitutive_amination_forming_aryl_aromatic_imine
type: substructure conversion
has parent: substitutive_imination-deimination

substitutive_imination-deimination
has child: substitutive_amination_forming_aryl_aromatic_imine
type: substructure conversion
has parent: nitrogen-related_substitution
has child: substitutive_amination_forming_imine

substitutive_amination_forming_imine
type: substructure conversion
has parent: substitutive_imination-deimination

substitutive_amination_forming_primary_amine
type: substructure conversion
has parent: substitutive_amination-deamination

substitutive_amination_forming_secondry_amine
type: substructure conversion
has parent: substitutive_amination-deamination

substitutive_amination_forming_tertiary_amine
type: substructure conversion
has parent: substitutive_amination-deamination

substitutive_amine_exchange_forming_ring
type: substructure conversion
has parent: substitutive_amination-deamination

substitutive_aminomutation
type: substructure conversion
has parent: substitutive_amination-deamination

substitutive_carbon-metal_bond_formation
type: substructure conversion
has parent: metal-related_substitution
has child: substitutive_carbon_metal_formation_on_alkyl

substitutive_carbon_metal_formation_on_alkyl
type: substructure conversion
has parent: substitutive_carbon-metal_bond_formation

substitutive_carbonyl_exchange
type: substructure conversion
has parent: substitutive_carboxylic_ester_formation

substitutive_carboxylic_ester_exchange
type: substructure conversion
has parent: substitutive_carboxylic_ester_formation

substitutive_epoxidation
type: substructure conversion
has parent: substitutive_hydroxy_ether_formation
has child: substitutive_etherification_on_alcohol_forming_epoxide
has child: substitutive_etherification_on_alkenyl_forming_epoxide
has child: substitutive_etherification_on_alkyl_forming_epoxide
has child: substitutive_etherification_on_peroxide_forming_epoxide
has child: substitutive_etherification_on_thioether_forming_epoxide

substitutive_etherification_on_alcohol_forming_epoxide
type: substructure conversion
has parent: substitutive_epoxidation

substitutive_etherification_on_alkenyl_forming_epoxide
type: substructure conversion
has parent: substitutive_epoxidation

substitutive_etherification_on_alkyl_forming_cyclic_hydroxy_ether
type: substructure conversion
has parent: substitutive_C-etherification_on_alkyl_forming_alkyl_ether

substitutive_etherification_on_alkyl_forming_epoxide
type: substructure conversion
has parent: substitutive_epoxidation

substitutive_etherification_on_peroxide_forming_epoxide
type: substructure conversion
has parent: substitutive_epoxidation

substitutive_etherification_on_thioether_forming_epoxide
type: substructure conversion
has parent: substitutive_epoxidation

substitutive_halogenization_on_alkenyl
type: substructure conversion
has parent: halogen-related_substitution
has child: substitutive_halogenization_on_alkenyl_forming_alkenyl_halide

substitutive_halogenization_on_alkenyl_forming_alkenyl_halide
type: substructure conversion
has parent: substitutive_halogenization_on_alkenyl
has child: substitutive_halogenization_on_alkyl

substitutive_halogenization_on_alkyl
type: substructure conversion
has parent: substitutive_halogenization_on_alkenyl_forming_alkenyl_halide
has child: substitutive_halogenization_on_alkyl_forming_alkenyl_halide
has child: substitutive_halogenization_on_alkyl_forming_alkyl_halide

substitutive_halogenization_on_alkyl_forming_alkenyl_halide
type: substructure conversion
has parent: substitutive_halogenization_on_alkyl

substitutive_halogenization_on_alkyl_forming_alkyl_halide
type: substructure conversion
has parent: substitutive_halogenization_on_alkyl

substitutive_halogenization_on_aryl
type: substructure conversion
has parent: halogen-related_substitution
has child: substitutive_halogenization_on_aryl_forming_aryl_halide

substitutive_halogenization_on_aryl_forming_aryl_halide
type: substructure conversion
has parent: substitutive_halogenization_on_aryl

substitutive_hydroxy_ether_exchange
type: substructure conversion
has parent: substitutive_hydroxy_ether_formation

substitutive_lactone_formation
type: substructure conversion
has parent: substitutive_carboxylic_ester_formation

substitutive_methylation_on_other_elements
type: substructure conversion
has parent: substitutive_methylation-demethylation

substitutive_methylmutation
type: substructure conversion
has parent: substitutive_C-methylation

substitutive_nitrogen-metal_bond_formation
type: substructure conversion
has parent: metal-related_substitution
has child: tetrapyrrole_coordination

substitutive_phosphorylation-dephosphorylation
type: substructure conversion
has parent: phosphorus-related_substitution
has child: substitutive_phosphorylation_forming_cyclic_phosphate_ester
has child: substitutive_phosphorylation_on_alcohol_forming_phosphate_ester
has child: substitutive_phosphorylation_on_alkyl_forming_phosphate_ester
has child: substitutive_phosphorylation_on_amine_forming_phosphoramide
has child: substitutive_phosphorylation_on_carboxylate_forming_acylphosphate
has child: substitutive_phosphorylation_on_enol_forming_phosphate_ester
has child: substitutive_phosphorylation_on_phenol_forming_phosphate_ester
has child: substitutive_phosphorylation_on_phosphate_forming_phosphate_ester
has child: substitutive_phosphorylation_on_phosphate_forming_phosphoanhydride

substitutive_phosphorylation_forming_cyclic_phosphate_ester
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_alcohol_forming_phosphate_ester
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_alkyl_forming_phosphate_ester
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_amine_forming_phosphoramide
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_carboxylate_forming_acylphosphate
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_enol_forming_phosphate_ester
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_phenol_forming_phosphate_ester
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_phosphate_forming_phosphate_ester
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_phosphorylation_on_phosphate_forming_phosphoanhydride
type: substructure conversion
has parent: substitutive_phosphorylation-dephosphorylation

substitutive_selenol_formation
type: substructure conversion
has parent: sulfur-related_substitution
has child: substitutive_selenol_formation_on_alkyl

substitutive_selenol_formation_on_alkyl
type: substructure conversion
has parent: substitutive_selenol_formation

substitutive_sulfate_formation
type: substructure conversion
has parent: sulfur-related_substitution
has child: substitutive_sulfate_formation_on_alcohol_forming_sulfate_ester
has child: substitutive_sulfate_formation_on_alkyl_forming_sulfonate
has child: substitutive_sulfate_formation_on_amine_forming_amine_sulfate
has child: substitutive_sulfate_formation_on_aryl_forming_sulfonate
has child: substitutive_sulfate_formation_on_ketone_forming_enol_sulfate_ester
has child: substitutive_sulfate_formation_on_ketone_forming_sulfonate
has child: substitutive_sulfate_formation_on_oxime_forming_oxime_sulfate_ester
has child: substitutive_sulfate_formation_on_phosphate_forming_phosphosulfate
has child: substitutive_sulfate_formation_on_thiol_forming_thiosulfate

substitutive_sulfate_formation_on_alcohol_forming_sulfate_ester
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_alkyl_forming_sulfonate
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_amine_forming_amine_sulfate
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_aryl_forming_sulfonate
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_ketone_forming_enol_sulfate_ester
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_ketone_forming_sulfonate
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_oxime_forming_oxime_sulfate_ester
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_phosphate_forming_phosphosulfate
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfate_formation_on_thiol_forming_thiosulfate
type: substructure conversion
has parent: substitutive_sulfate_formation

substitutive_sulfide_formation
type: substructure conversion
has parent: sulfur-related_substitution
has child: substitutive_sulfide_formation_on_alkyl_forming_thioether
has child: substitutive_sulfide_formation_on_alkyl_forming_disulfide
has child: substitutive_sulfide_formation_on_aryl_forming_aryl_thioether
has child: substitutive_sulfide_formation_on_imine_forming_imine_thioether
has child: substitutive_sulfide_formation_on_thiol_forming_disulfide
has child: substitutive_thioether_mutation

substitutive_sulfide_formation_on_alkyl_forming_cyclic_thioether
type: substructure conversion
has parent: substitutive_sulfide_formation_on_alkyl_forming_thioether

substitutive_sulfide_formation_on_alkyl_forming_thioether
has child: substitutive_sulfide_formation_on_alkyl_forming_cyclic_thioether
type: substructure conversion
has parent: substitutive_sulfide_formation

substitutive_sulfide_formation_on_alkyl_forming_disulfide
type: substructure conversion
has parent: substitutive_sulfide_formation

substitutive_sulfide_formation_on_aryl_forming_aryl_thioether
type: substructure conversion
has parent: substitutive_sulfide_formation

substitutive_sulfide_formation_on_imine_forming_imine_thioether
type: substructure conversion
has parent: substitutive_sulfide_formation

substitutive_sulfide_formation_on_thiol_forming_disulfide
type: substructure conversion
has parent: substitutive_sulfide_formation

substitutive_thioether_mutation
type: substructure conversion
has parent: substitutive_sulfide_formation

substitutive_thiolation
type: substructure conversion
has parent: sulfur-related_substitution
has child: substitutive_thiolation_on_alkyl_formation_thiol
has child: substitutive_thiolation_on_aryl_forming_aryl_thiol
has child: substitutive_thiolation_on_thiol_forming_persulfide

substitutive_thiolation_on_alkyl_formation_thiol
type: substructure conversion
has parent: substitutive_thiolation

substitutive_thiolation_on_aryl_forming_aryl_thiol
type: substructure conversion
has parent: substitutive_thiolation

substitutive_thiolation_on_thiol_forming_persulfide
type: substructure conversion
has parent: substitutive_thiolation

tertiary_carbon_carboxylate_epimerization
type: substructure conversion
has parent: C1_residue_epimerization

tetrapyrrole_coordination
type: substructure conversion
has parent: substitutive_nitrogen-metal_bond_formation

transalkylation_on_cyanide
type: substructure conversion
has parent: additive_alkynylation-dealkynylation